Effect of 6-month S-methylmethionine intake on the quality of life and dyspepsia symptoms in patients with chronic gastritis

Abstract

S-methylmethionine (methylmethionine sulfonium chloride), better known as vitamin U, is a metabolic substrate that affects many metabolic processes in the human organism. Since its discovery, a large number of studies has been produced demonstrating its safety and effectiveness in various diseases, especially in diseases of the gastrointestinal tract.

The purpose of the study was to evaluate the effect of methylmethionine sulfonium chloride (vitamin U) intake on the symptoms of dyspepsia and the quality of life of patients with chronic gastritis.

Material and methods. The study included 37 patients (21 men and 16 women) aged 35–60 years with chronic gastritis of various etiologies. After inclusion in the study, all patients were prescribed S-methylmethionine at a dose of 300 mg per day. Clinical manifestations of dyspepsia were assessed using the GSRS questionnaire (Gastrointestinal Symptom Rating Scale), quality of life was assessed using the SF 36 questionnaire. The survey was conducted before the start of the therapy, after 3 and 6 months of complex diet therapy.

Results. The most pronounced manifestations were dyspeptic (from 3 to 9 points) and diarrheal syndromes (from 2 to 5 points). Other indicators of the GSRS scale did not exceed 4 points. The total score was 15 points. By the 3rd month of therapy, there was a statistically significant decrease in the total score to 9 points (p<0.05). By the 6th month of therapy, the total GSRS score averaged 5.5 points (p<0.05). According to the SF 36 questionnaire, by the end of the 3rd month of therapy, indicators such as PF – physical functioning, BP – Bodily pain and SF – social functioning improved. By the end of the 6th month of therapy, several other indicators also improved (RP – role-physical functioning, GH – general perception of health, VT – viability, RE – Role-Emotional; MH – mental health) (p<0.05).

Conclusion. The study showed that the appointment of dietary supplements containing methylmethionine sulfonium chloride at a dose of 300 mg per day helps to reduce the severity of dyspeptic symptoms in patients with chronic gastritis and their quality of life.

Keywords:methylmethionine sulfonium chloride; vitamin U; chronic gastritis; H. pylori; dyspeptic syndrome; quality of life

Funding. The study was not sponsored.

Conflict of interest. The authors declare no conflicts of interest.

Contribution. Concept and design of the study – Drozdov V.N.; collection of material – Astapovskiy A.A., Tormyshov I.A.; processing of material – Ponomarenko T.M.; statistical processing – Drozdov V.N.; writing the text – Pavlova L.I., Astapovskiy A.A.; editing the text, approval of the final version of the article, responsibility for the integrity of all parts of the article – all authors.

For citation: Drozdov V.N., Shih E.V., Astapovskij A.A., Pavlova L.I., Tormyshov I.A. Effect of 6-month s-methylmethionine intake on the qua-

lity of life and dyspepsia symptoms in patients with chronic gastritis. Voprosy pitaniia [Problems of Nutrition]. 2023; 92 (2): 80–6. DOI: https://doi.org/10.33029/0042-8833-2023-92-2-80-86 (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Viktor A. Tutelyan
Full Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Scientific Director of the Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia)

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