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5 . 2020

The comparative analysis of the spectrum of sensitization to food, pollen and fungal allergens in patients with atopic dermatitis and psoriasis

Abstract

The relevance of the study of psoriatic disease is due to the insufficient effectiveness of existing etiotropic and pathogenetic methods of treatment, which confirms the necessity to search for new approaches in the research of psoriasis, including those from the standpoint of etiopathogenesis. In the literature, there is information about the combination of atopic dermatitis and psoriasis, which does not exclude a commonality of the causes and mechanisms leading to damage to the skin.

The aim of the work was to study and conduct a comparative analysis of the sensitization spectrum of patients with psoriasis and atopic dermatitis to food, pollen and fungal allergens.

Material and methods. A prospective study was conducted on patients with psoriasis (1st, n=20) and atopic dermatitis (2ndgroup, n=20) aged 18 to 57 years. A specific aller-gological examination was performed (collection of an allergological history, determination of the spectrum of sensitization to food, pollen and fungal allergens by prick testing). Statistical data processing was carried out by methods of variational analysis using the t-criterion for qualitative characteristics.

Results and discussion. No statistically significant differences in sensitization to allergens of animal origin between the examined groups were detected. The sensitization to rice and soy was statistically significantly more often noted in patients with psoriasis, in comparison with patients with atopic dermatitis: 33.3 (n=6/18) vs 5.2% (n=1/19), p=0.03 and 66.7 (n=10/15) vs 29.4% (n=5/17), p=0.04. It was determined that sensitization to plant pollen allergens was statistically significantly more often detected in patients with atopic dermatitis compared to the group with psoriasis (72.5 vs 54.4%, p=0.02). It was noted that in the group of patients with psoriasis compared to the group of patients with atopic dermatitis, sensitization to fungi of the genus Candida albicans, Alternaria alternata, Penicillium notatum was more often, however, the differences did not reach statistical significance.

Conclusion. Thus, in our study, we determined the presence of sensitization to food, pollen and fungal allergens not only in patients with atopic dermatitis, but also in psoriasis. So, sensitization to food and pollen allergens is more often determined in atopic dermatitis, and to some food and fungal allergens - in psoriasis. Preliminary prick testing guides us in further application of other methods of specific allergological diagnostics: elimination and provocative tests, and the appointment of personalized therapy.

Keywords:psoriasis, atopic dermatitis, food allergy, sensitization

Funding. The study was supported by Presidential Grant Council (MK-396.2020.7).

Conflict of interests. The authors of this article declare no conflict of interest.

For citation: Barilo A.A., Smirnova S.V. The comparative analysis of the spectrum of sensitization to food, pollen and fungal allergens in patients with atopic dermatitis and psoriasis. Voprosy pitaniia [Problems of Nutrition]. 2020; 89 (5): 28-34. DOI: https://www.doi.org/10.24411/0042-8833-2020-10063 (in Russian)

References

1. Boehncke W.H., Schön M.P. Psoriasis. Lancet. 2015; 386: 983–94. DOI: 10.1016/S0140-6736(14)61909-7.

2. Ayala-Fontanez N., Soler D.C., McCormick T.S. Current knowledge on psoriasis and autoimmune diseases. Psoriasis. 2016; 6: 732. DOI: 10.2147/PTT.S64950.

3. Smirnova S.V., Barilo A.A., Smol’nikova M.V. The prognostic value of clinical and anamnestic markers of psoriatic arthritis. Klinicheskaya dermatologiya i venerologiya [Clinical Dermatology and Venerology]. 2016; 15 (1): 23–7. (in Russian).

4. Di Meglio P., Villanova F., Nestle F.O. Psoriasis. Cold Spring Harb Perspect Med. 2014; 4 (8): 1–30. DOI: 10.1101/cshperspect.a015354.

5. Lowes M.A., Bowcock A.M., Krueger J.G. Pathogenesis and therapy of psoriasis. Nature. 2007; 445: 866–73. DOI: 10.1038/nature05663.

6. Smirnova S.V., Smol’nikova M.V., Barilo A.A. The concentration of IL-4, IL-6, IL-10, TNF-α in the serum of psoriasis and psoriatic arthritis patients. Tsitokiny i vospalenie [Cytokines and Inflammation]. 2015; 16 (3): 31–2. (in Russian).

7. Barilo A.A., Smirnova S.V., Smol’nikova M.V. Immunological indicators of patients with psoriasis in different age groups. Rossiyskiy immsunologicheskiy zhurnal [Russian Journal of Immunology]. 2017; 11 (4): 680–1. (in Russian).

8. Kabashima K., Nomura T. Revisiting murine models for atopic dermatitis and psoriasis with multipolar cytokine axes. Curr Opin Immunol. 2017; 48: 99–107. DOI: 10.1016/j.coi.2017.08.010.

9. Griffiths C.E.M., van de Kerkhof P., Czarnecka-Operacz M. Psoriasis and atopic dermatitis. Dermatol Ther (Heidelb). 2017; 7: 31–41. doi: 10.1007/s13555-016-0167-9.

10. Guttman-Yassky E., Krueger J.G. Atopic dermatitis and psoriasis: two different immune diseases or one spectrum? Curr Opin Immunol. 2017; 48: 68–73. DOI: 10.1016/j.coi.2017.08.008.

11. Klonowska J., Gleń J., Nowicki R.J., et al. New cytokines in the pathogenesis of atopic dermatitis – new therapeutic targets. Int J Mol Sci. 2018; 19 (10): 3086. doi: 10.3390/ijms19103086.

12. Barry K., Zancanaro P., Casseres R., et al. Concomitant atopic dermatitis and psoriasis - a retrospective review. J Dermatolog Treat. 2019; Dec 5: 1–5. DOI: 10.1080/09546634.2019.1702147.

13. Choy D.F., Hsu D.K., Seshasayee D., et al. Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation. J Allergy Clin Immunol. 2012; 130 (6): 1335–43. DOI: 10.1016/j.jaci.2012.06.044.

14. Furue M., Kadono T. «Inflammatory skin march» in atopic dermatitis and psoriasis. Inflamm Res. 2017; 66 (10): 833–42. DOI: 10.1007/s00011-017-1065-z.

15. Sidler D., Wu P., Herro R., et al. TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis. Nat Commun. 2017; 8: 15395. DOI: 10.1038/NCOMMS15395.

16. Ünal E.S., Gül Ü., Dursun A.B., et al. Prediction of atopy via total immunoglobulin E levels and skin prick tests in patients with psoriasis. Turk J Med Sci. 2017; 47 (2): 577–82. DOI: 10.3906/sag-1601-133.

17. Brunner P.M., Israel A., Zhang N., et al. Early-onset pediatric atopic dermatitis is characterized by TH2/TH17/TH22-centered inflammation and lipid alterations. J Allergy Clin Immunol. 2018; 141 (6): 2094–106. DOI: 10.1016/j.jaci.2018.02.040.

18. Sanyal R.D., Pavel A.B., Glickman J., et al. Atopic dermatitis in African American patients is TH2/TH22-skewed with TH1/TH17 attenuation. Ann Allergy Asthma Immunol. 2019; 122 (1) 99–110. DOI: 10.1016/j.anai.2018.08.024.

19. Weryńska-Kalemba M., Filipowska-Grońska A., Kalemba M., et al. Analysis of selected allergic reactions among psoriatic patients. J Postepy Dermatol Alergol. 2016; 33 (1): 18–22. DOI: 10.5114/pdia.2014.44015.

20. Malik K., Ungar B., Garcet S., et al. Dust mite induces multiple polar T cell axes in human skin. Clin Exp Allergy. 2017; 47 (12): 164860. DOI: 10.1111/cea.13040.

21. Barilo A.A., Smirnova S.V. The role of nutritional factors and food allergy in the development of psoriasis. Voprosy pitaniia [Problems of Nutrition]. 2020; 89 (1): 60–8. (in Russian).

22. Dey D., Mondal P., Laha A., et al. Sensitization to common aeroallergens in the atopic population of West Bengal, India: an investigation by skin prick test. Int Arch Allergy Immunol. 2019; 178 (1): 60–5. DOI: 10.1159/000492584.

23. Menter A., Korman N.J., Elmets C.A., et al. Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 3. Guidelines of care for the management and treatment of psoriasis with topical therapies. J Am Acad Dermatol. 2009; 60 (4): 643–59. DOI: 10.1016/j.jaad.2008.12.032.

24. Benedé S., Belen Blázquez A., Chiang D., et al. The rise of food allergy: environmental factors and emerging treatments. EBioMedicine. 2016; 7: 27–34. DOI: 10.1016/j.ebiom.2016.04.012.

25. Hosseini P., Khoshkhui M., Hosseini R.F., et al. Investigation of the relationship between atopy and psoriasis. Postepy Dermatol Alergol. 2019; 36 (3): 276–81. DOI: 10.5114/ada.2019.85639.

26. Tsarev S.V. Allergy to fungi: features of clinical manifestations and diagnosis. Astma i allergiya [Asthma and Allergy]. 2015; (3): 37. (in Russian).

27. Čelakovská J., Bukač J. Hypoallergenic diet can influence the severity of atopic dermatitis. Indian J Dermatol. 2013; 58 (3): 239. DOI: 10.4103/0019-5154.

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CHIEF EDITOR
CHIEF EDITOR
Viktor A. Tutelyan
Full Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Scientific Director of the Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia)
Medicine today

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