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3 . 2021

Diet therapy program for weight loss and assessment of its effectiveness in overweight and obese persons

Abstract

The basic method of obesity treatment is diet therapy aimed at long-term maintenance of negative energy balance by restricting the caloric intake of the diet.

The aim - to evaluate the effectiveness of the diet therapy program for weight loss with the use of a complex of amino acids and glucomannan.

Material and methods. To conduct the study, in accordance with the inclusion and exclusion criteria, a sample of 33 overweight or obese people was formed, of which 30 people (16 men and 14 women) took part in the study. The age of the persons included in the study ranged from 20 to 59 years (average 41.0±1.73 years), body mass index- from 26.4 to 45.5 kg/m2 (average 35.5±0.8 kg/m2), waist circumference as a criterion for abdominal obesity - 110.4±2.4 cm. Participants three times a day (7.00-9.00, 12.00-14.00 and 16.00-18.00) received within 14 days 15 g of powder dissolved in 200 ml of water containing whey protein concentrate, potassium (618 mg in the form of citrate), glucomannan, taurine (290 mg), zinc (2.5 mg in the form of sulfate), vitamins B6 (1.4 mg) and B12 (3 mcg), and 2 capsules containing L-isoleucine (340 mg), L-ornithine-alpha-ketoglutarate (290 mg), L-citrulline-DL-malate (290 mg) and L-tryptophan (80 mg). In the evening, the main meal was dinner, which included a protein dish with vegetables and herbs. The energy value of the evening meal was 400 kcal (1675 kJ), the proportion of protein, fat and carbohydrates was 40, 30 and 30%, respectively, of the calorie content of the evening meal.

Results. It was shown that the use of a 14-day course of the diet therapy program to reduce body weight was accompanied by a statistically significant decrease in body weight on average 6.3% of the initial level, an improvement in body composition indicators (a rather pronounced decrease in body fat mass by 9.2%, p<0.001, with a smaller decrease in lean body mass and skeletal muscle mass, respectively by 3.9 and 4.1%, p<0.001) and metabolic blood parameters (a decrease in serum glucose concentration, total cholesterol, triglycerides, total bilirubin andgamma-glutamyltransferase by 12.5, 15.0, 35.0,22.8 and 34.6% respectively).

Conclusion. Application of the diet therapy program for weight loss «Non-invasive liposuction» allows us to recommend its use in obese patients in order to increase the effectiveness of therapeutic and prophylactic measures in correcting excess body weight, improving the parameters of carbohydrate and lipid metabolism, and the functional state of the biliary system.

Keywords:biologically active food supplements, overweight, obesity, diet therapy, body composition

Funding. Research work was carried out at the expense of extrabudgetary funds.

Conflict of interest. The authors declare no conflicts of interest.

For citation: Sharafetdinov Kh.Kh., Derbeneva S.A., Zainudinov Z.M., Zavistyaeva TYu., Plotnikova O.A., Pilipenko V.V., Zaletova T.S. Diet therapy program for weight loss and assessment of its effectiveness in overweight and obese persons. Voprosy pitaniia [Problems of Nutrition]. 2021; 90 (3): 84-92. DOI: https://doi.org/10.33029/0042-8833-2021-90-3-84-92 (in Russian)

References

1. Ametov A.S. Obesity. A modern view of pathogenesis and therapy: a tutorial. Moscow: GЕОТАR-Media, 2019; (1): 384 p. (in Russian)

2. Sharafetdinov Kh.Kh., Plotnikova O.A. Obesity as a global challenge of the 21st century: clinical medical nutrition, prevention and therapy. Voprosy pitaniia [Problems of Nutrition]. 2020; 89 (4): 161–71. DOI: https://doi.org/10.24411/0042-8833-2020-10050 (in Russian)

3. Seravalle G., Grassi G. Obesity and hypertension. Pharmacol Res. 2017; 122: 1–7. DOI: https://doi.org/10.1016/j.phrs.2017.05.013

4. Bray G.A., Kim K.K., Wilding J.P.H. Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation. Obes Rev. 2017; 18 (7): 715–23. DOI: https://doi.org/10.1111/obr.12551

5. Hales C.M., Carroll M.D., Fryar C.D., Ogden C.L. Prevalence of obesity and severe obesity among adults: United States, 2017–2018. NCHS Data Brief, No. 360. Hyattsville, MD: National Center for Health Statistics. 2020. URL: https://www.cdc.gov/nchs/data/databriefs/db360-h.pdf

6. Balanova Yu.A., Shal’nova S.A., Deev А.D., et al. Obesity in the Russian population – prevalence and associations with risk factors for chronic non-communicable diseases. Rossiyskiy kardiologicheskiy zhurnal [Russian Journal of Cardiology]. 2018; 23 (6): 123–30. DOI: https://doi.org/10.15829/1560-4071-2018-6-123-130 (in Russian)

7. Tino S., Mayanja B.N., Mubiru M.C., Eling E., et al. Prevalence and factors associated with overweight and obesity among patients with type 2 diabetes mellitus in Uganda – a descriptive retrospective study. BMJ Open. 2020; 10 (11): e039258. DOI: https://doi.org/10.1136/bmjopen-2020-039258

8. Kachur S., Lavie C.J., de Schutter A., et al. Obesity and cardiovascular diseases. Minerva Med. 2017; 108 (3): 212–28. DOI: https://doi.org/10.23736/S0026-4806.17.05022-4

9. Owen C.G., Kapetanakis V.V., Rudnicka A.R., et al. Body mass index in early and middle adult life: prospective associations with myocardial infarction, stroke and diabetes over a 30-year period: the British Regional Heart Study. BMJ Open. 2015; 5 (9): e008105. DOI: https://doi.org/10.1136/bmjopen-2015-008105

10. Joshy G., Korda R.J., Attia J., et al. Body mass index and incident hospitalisation for cardiovascular disease in 158 546 participants from the 45 and Up Study. Int J Obes (Lond). 2014; 38 (6): 848–56. DOI: https://doi.org/10.1038/ijo.2013.192

11. Leszczak J., Czenczek-Lewandowska E., Przysada G., et al. Association between body mass index and results of rehabilitation in patients after stroke: a 3-month observational follow-up study. Med Sci Monit. 2019; 25: 4869–76. DOI: https://doi.org/10.12659/MSM.915586

12. Ackerman I.N., Bohensky M.A., Zomer E., et al. The projected burden of primary total knee and hip replacement for osteoarthritis in Australia to the year 2030. BMC Musculoskelet Disord. 2019; 20 (1): 90. DOI: https://doi.org/10.1186/s12891-019-2411-9

13. Lin C.Y., Shih T.S., Liou S.H., et al. Predictors for progression of sleep disordered breathing among public transport drivers: a 3-year follow-up study. J Clin Sleep Med. 2015; 11 (4): 419–25. DOI: https://doi.org/10.5664/jcsm.4596

14. Patro M., Gothi D., Ojha U.C., et al. Predictors of obesity hypoventilation syndrome among patients with sleep-disordered breathing in India. Lung India. 2019; 36 (6): 499–505. DOI: https://doi.org/10.4103/lungindia.lungindia_61_19

15. Avgerinos K.I., Spyrou N., Mantzoros C.S., Dalamaga M. Obesity and cancer risk: Emerging biological mechanisms and perspectives. Metabolism. 2019; 92: 121–35. DOI: https://doi.org/10.1016/j.metabol.2018.11.001

16. Arnold M., Pandeya N., Byrnes G., et al. Global burden of cancer attributable to high body-mass index in 2012: a population-based study. Lancet Oncol. 2015; 16 (1): 36–46. DOI: https://doi.org/10.1016/S1470-2045(14)71123-4

17. WHO. 2015 Obesity and overweight. Geneva: World Health Organization, 2015. URL: http://www.who.int/mediacentre/factsheets/fs311/en/

18. Cheskin L.J., Poddar K.H. Obesity management. In: A. Catharine Ross et al. (eds). Modern Nutrition in Health and Disease. 11th. Lippincott Williams and Wilkins; Wolters Kluwer, 2014: 786–99.

19. Ge L., Sadeghirad B., Ball G.D.C., et al. Comparison of dietary macronutrient patterns of 14 popular named dietary programmes for weight and cardiovascular risk factor reduction in adults: systematic review and network meta-analysis of randomised trials. BMJ. 2020; 369: m696. DOI: https://doi.org/10.1136/bmj.m696

20. Jensen M.D., Ryan D.H., Apovian C.M., et al. 2013 AHA/ACC/TOS Guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. J Am Coll Cardiol. 2014; 63 (25 Pt B): 2985–3023. DOI: https://doi.org/10.1016/j.jacc.2013.11.004

21. EFSA Panel on Dietetic Products, Nutrition and Allergies. Glucomannan related health claims. EFSA J. 2010; 8 (10): 1798.

22. EFSA Panel on Dietetic Products, Nutrition and Allergies. Essential composition of total diet replacements for weight control. EFSA J. 2015; 13 (1): 3957.

23. Zhernakova Yu.V., Zheleznova E.A., Chazova I.E., et al. The prevalence of abdominal obesity in the constituent entities of the Russian Federation and its relationship with socio-economic status, the results of the ESSE-RF epidemiological study. Terapevticheskiy arkhiv [Therapeutic Archive]. 2018; 90 (10): 14–22. DOI: https://doi.org/10.26442/terarkh2018901014-22 (in Russian)

24. Rakel D. Integrative Medicine. E-Book. Elsevier Health Sciences, 2017.

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CHIEF EDITOR
CHIEF EDITOR
Viktor A. Tutelyan
Full Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Scientific Director of the Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia)

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