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4 . 2021

Role of tomatoes and products thereof in human healthy diet

Abstract

Tomatoes are an essential part of the diet. Epidemiological studies have established a link between the consumption of tomatoes, which contain carotenoids, and a reduction in the risk of diseases such as cancer and cardiovascular diseases. Ripe tomato fruits are dark red in color due to the carotenoid lycopene, which is synthesized during fruit ripening. The aim of this review was to summarize and analyze modern data on the role of tomatoes and their processed products in healthy human nutrition.

Results. The beneficial effects of this vegetable on bone health, cognitive function, and the cardiovascular system have been studied. However, large intervention studies are needed to confirm a real causal relationship between tomato consumption and the risk of these diseases. Given the presence of various useful bioactive components in tomatoes, the results of most studies provide a reason to include more tomatoes and their processed products in the diet. However, both excessive and regular consumption of this vegetable can cause some side effects in the human body.

Conclusion. Recent studies highlight the relationship between tomato consumption and a reduced risk of various diseases such as obesity, hypercholesterolemia, cardiovascular disease and cancer. Tomatoes, thanks to the bioactive substances they contain, with an adequate level of consumption, can become effective component of a healthy diet.

Keywords:tomatoes, lycopene, antioxidants, cardiovascular diseases, prostate cancer

Funding. The study did not have sponsorship.

Conflict of interest. The authors declare no conflict of interest.

For citation: Shikh E.V., Elizarova E.V., Makhova A.A., Bragina TV. Role of tomatoes and products thereof in human healthy diet. Voprosy pitaniia [Problems of Nutrition]. 2021; 90 (4): 129-37. DOI: https://doi.org/10.33029/0042-8833-2021-90-4-129-137 (in Russian)

References

1. Tohge T., Fernie A.R. Metabolomics-inspired insight into developmental, environmental and genetic aspects of tomato fruit chemical composition and quality. Plant Cell Physiol. 2015; 56 (9): 1681–96. DOI: https://doi.org/10.1093/pcp/pcv093

2. Abreu A.C., Fernández I. NMR metabolomics applied on the discrimination of variables influencing tomato (Solanum lycopersicum). Molecules. 2020; 25 (16): 3738. Epub 2020 Aug 16. DOI: https://doi.org/10.3390/molecules25163738

3. Ali M.Y., Sina A.A., Khandker S.S., Neesa L., Tanvir E.M., Kabir A., et al. Nutritional composition and biologically active compounds of tomatoes and their impact on human health and diseases: review. Products. 2020; 10 (1): 45. DOI: https://doi.org/10.3390/foods10010045

4. Salehi B., Sharifi-Rad R., Sharopov F., et al. Beneficial effects and potential risks of tomato consumption for human health: an overview. Nutrition. 2019; 62: 201–8. DOI: https://doi.org/10.1016/j.nut.2019.01.012

5. Azariz L., Elblidi S., Yahyaoui A., Fekhaoui M. Assessment of phytoavailability in the cherry tomato plants exposed to lead and chromium in a nutrient solution. J Geosci Environ Protect. 2017; 5: 176–88.

6. Mapelli-Brahm Р., Corte-Real J., Meléndez-Martínez A.J., Bohn T. Bioaccessibility of phytoene and phytofluene is superior to other carotenoids from selected fruit and vegetable juices. Food Chem. 2017; 229: 304–11. DOI: https://doi.org/10.1016/j.foodchem.2017.02.074

7. Melendez-Martinez A.J., Mapelli-Brahm P., Benitez-Gonzalez A., Stinco C.M. A comprehensive review on the colorless carotenoids phytoene and phytofluene. Arch Biochem Biophys. 2015; 572: 188–200.

8. Ivanova N.N., Khomich L.M. Beketova N.A. The nutrient profile of tomato juice. Voprosy pitaniia [Problems of Nutrition]. 2018; 87 (2): 53–64. DOI: https://doi.org/10.24411/0042-8833-2018-10019 (in Russian)

9. Nicklas T.A., O’Neil C., Fulgoni V. Consumption of 100% fruit juice is associated with better nutrient intake and diet quality but not with weight status in children: NHANES 2007–2010. Int J Child Health Nutr. 2015; 4: 112–21.

10. Jie Zheng, Yue Zhou, Sha Li, Pei Zhang, Tong Zhou, Dong-Ping Xu, et al. Effects and mechanisms of fruit and vegetable juices on cardiovascular diseases. Int J Mol Sci. 2017; 18: 555.

11. Fentik D. Review on genetics and breeding of tomato (Lycopersicon esculentum Mill). Adv Crop Sci Tech. 2017; 5: 306.

12. Marcotorchino J., Romier B., Gouranton E., Riollet C., Gleize B., Malezet-Desmoulins C., et al. Lycopene attenuates LPS-induced TNF-α secretion in macrophages and inflammatory markers in adipocytes exposed to macrophageconditioned media. Mol Nutr Food Res. 2012; 56: 725–32.

13. Ayumi Nakamura, Chieko Itaki, Ayako Saito, TokoYonezawa, Koichi Aizawa, Ayumi Hirai, et al. Possible benefits of tomato juice con¬sumption: a pilot study on irradiated human lymphocytes from healthy donors. Nutr J. 2017; 16: 27. DOI: https://doi.org/10.1186/s12937-017-0248-3

14. Friedman M. Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes. J Agric Food Chem. 2015; 63 (13): 3323–37. DOI: https://doi.org/10.1021/acs.jafc.5b00818

15. Xu X., Li J., Wang X., Wang S., Meng S., Zhu Y., et al. Tomato consumption and prostate cancer risk: a systematic review and meta-analysis. Sci Rep. 2016; 6: 37091.

16. Arballo J., Amengual J., Erdman J.W. Jr. Lycopene: a critical review of digestion, absorption, metabolism, and excretion. Аntioxidants (Basel). 2021; 10 (3): 342. DOI: https://doi.org/10.3390/antiox10030342

17. Soares N.D.C.P., Machado C.L., Trindade B.B., do Canto Lima I.C., Gimba E.R.P., Teodoro A.J., et al. Lycopene extracts from different tomato-based food products induce apoptosis in cultured human primary prostate cancer cells and regulate tp53, bax and bcl-2 transcript expression. Asian Pac J Cancer Prev. 2017; 18: 339–45.

18. Wang Y., Cui R., Xiao Y., Fang J., Xu Q. Correction: effect of carotene and lycopene on the risk of prostate cancer: a systematic review and dose-response meta-analysis of observational studies. PLoS One. 2015; 10 (10): e0140415.

19. Key T.J., Appleby P.N., Travis R.C., et al. Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies. Am J Clin Nutr. 2015; 102 (5): 1142–57.

20. Rao A.V., Young G.L., Rao L.G. (eds). Lycopene and tomatoes in human nutrition and health. Boca Raton, FL: CRC Press. 2018: 50 p. ISBN 9781466575370.

21. Badimon L., Vilahur G., Padro T. Nutraceuticals and atherosclerosis: human trials. Cardiovasc Ther. 2010; 28 (4): 202–15.

22. Hirose A., Terauchi M., Tamura M., et al. Tomato juice intake increases resting energy expenditure and improves hypertriglyceridemia in middle-aged women: an open-label, single-arm study. Nutr J. 2015; 14: 34. DOI: https://doi.org/10.1186/s12937-015-0021-4

23. Cheng H.M., Koutsidis G., Lodge J.K., Ashor A.W., Siervo M., Lara J. Lycopene and tomato and risk of cardiovascular diseases: a systematic review and metaanalysis of epidemiological evidence. Crit Rev Food Sci Nutr. 2017; 11: 1–18.

24. Petyaev I.M. Lycopene deficiency in ageing and cardiovascular disease. Oxid Med Cell Longev. 2016; 2016: 3218605.

25. Fuentes E.J., Astudillo L.A., Gutierrez M.I., Contreras S.O., Bustamante L.O., Rubio P.I., et al. Fractions of aqueous and methanolic extracts from tomato (Solanum lycopersicum L.) present platelet antiaggregant activity. Blood Coagul Fibrinolysis. 2012; 23: 109–17.

26. Perveen R., Suleria H.A.R., Anjum F.M., Butt M.S., Pasha I., Ahmad S. Tomato (Solanum lycopersicum) carotenoids and lycopenes chemistry; metabolism, absorption, nutrition, and allied health claims — a comprehensive review. Crit Rev Food Sci Nutr. 2015; 55: 919–29.

27. Wise L.A., Wesselink A.K., Bethea T.N., Brasky T.M., Wegienka G., Harmon Q., et al. Intake of lycopene and other carotenoids and incidence of uterine leiomyomata: a prospective ultrasound study. J Acad Nutr Diet. 2021; 121 (1): 92–104. DOI: https://doi.org/10.1016/j.jand.2020.08.013

28. Jarosz M., Taraszewska A. Risk factors for gastroesophageal reflux disease: the role of diet. Przegla̜d Gastroenterol. 2014; 9: 297–301.

29. Shikh E.V., Makhova A.A., Astapovsky A.A., Perkov A.V. Prospects of probiotic strains of bifidobacteria and enterococcus in treatment and prevention of diseases in gastroenterology. Voprosy pitaniia [Problems of Nutrition]. 2021; 90 (2): 15–25. DOI: https://doi.org/10.33029/0042-8833-2021-90-2-15-25 (in Russian)

30. Sterns R.H., Grieff M., Bernstein P.L. Treatment of hyperkalemia: something old, something new. Kidney Int. 2016; 89: 546–54.

31. Siener R., Seidler A., Voss S., Hesse A. The oxalate content of fruit and vegetable juices, nectars and drinks. J Food Comp Anal. 2016; 45: 108–12.

32. Bassaly R., Downes K., Hart S. Dietary consumption triggers in interstitial cystitis/bladder pain syndrome patients. Female Pelvic Med Reconstr Surg. 2011; 17: 36–9.

33. Mamegani E. The comparison of dietary intake of effective foods on clinical outcomes of rheumatoid arthritis: a case-control study. Yafteh. 2011; 12: 51–60.

34. Slavin M., Ailani J. A clinical approach to addressing diet with migraine patients. Curr Neurol Neurosci Rep. 2017; 17: 17.

35. Zukiewicz-Sobczak W.A., Wroblewska P., Adamczuk P., Kopczynski P. Causes, symptoms and prevention of food allergy. Postȩpy Dermatol Alergol. 2013; 30: 113–6.

36. Welter S. Impact of biotic factors on the allergenic potential of tomato and identification of cyclophilin as a new putative tomato allergen. Doctoral Thesis, 2014.

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CHIEF EDITOR
CHIEF EDITOR
Viktor A. Tutelyan
Full Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Scientific Director of the Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia)

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