Vitamin supply of patients with type 2 diabetes mellitus complicated by nephropathy

Abstract

Insufficient vitamin content in the diet is a risk factor for the development of various diseases and their progression, and drug therapy can also contribute to the development of a deficiency of these micronutrients. Data on vitamin sufficiency of patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) are needed to develop measures to improve it.

The aim of the research was to compare vitamin status of patients with T2DM without DN and those with T2DM complicated by nephropathy by assessing vitamin blood level and urinary excretion.

Material and methods. In a single-stage research, 57 patients with T2DM and concomitant obesity (14 men, 43 women aged 42–75 years) have been examined. The 1st group included 26 patients with T2DM (7 men and 19 women, BMI 41.5±1.7 kg/m2) with glycated hemoglobin (HbA1c) – 8.0±1.4%, blood serum glucose level 8.1±0.6 mmol/l, glomerular filtration rate (GFR) – 86.7±3.0 ml/min per 1.73 m2, microalbuminuria – 18.0±2.0 mg/day. The 2nd group included 31 patients with T2DM complicated by DN (7 men and 24 women, BMI 42.5±1.3 kg/m2), with an HbA1c level of 6.4±0.2%, blood serum glucose level 6.8±0.3 mmol/l, GFR – 62.8±2.7 ml/min per 1.73 m2, microalbuminuria – 59.5±22.5 mg/day. The determination of vitamins С (ascorbic acid), A (retinol), E (α- and γ-tocopherols), D [25(OH)D], B2 (riboflavin) and β-carotene in blood serum and vitamins C (ascorbic acid), B1 (thiamine), B2 (riboflavin) and B6 (4-pyridoxic acid) in the morning portion of urine collected on an empty stomach within 40–120 min was carried out. The vitamin status was assessed based on the concentration of vitamins in blood serum and urinary excretion relative to the lower limit of the norm, as well as using the criteria for the optimal supply and 2 molar ratios.

Results. Compared to patients with T2DM without nephropathy, patients with DN were better provided with vitamins B2, A and β-carotene: vitamin B2 deficiency was found 3.2 fold less often (in 9.7%), β-carotene – 1.8 fold less often (in 35.5%), non-optimal retinol level occurred twice less often (in 41.9%). At the same time, serum α-tocopherol level below the optimal level was found in 67.7% of individuals versus 50% among patients with T2DM without nephropathy, with a significantly reduced urinary excretion of vitamins B1 and B2. With the exception of one man, the rest of the DN patients had a deficiency or lack of vitamin D. The characteristic features of the vitamin status of patients in both groups were the complete absence of individuals who were simultaneously optimally provided with all the studied vitamins and β-carotene (when assessing the vitamin status using both the absolute serum vitamer levels and 2 additional molar ratios), and a high frequency of detection of several simultaneously non-optimal vitamin status indicators. A negative correlation was found between blood serum level of β-carotene and glycemia (ρ=-0.359, p=0.006), as well as GFR (ρ=-0.289, р=0.029) and positive with high-density lipoprotein cholesterol (ρ=0.423, р=0.001), that indicated the need to increase this antioxidant blood level in patients with T2DM. The presence of a negative correlation between the concentration ratio of vitamins C and E and glucosuria (ρ=-0.288, p=0.033) and postprandial glycemia (ρ=-0.313, p=0.031) indicated the need to maintain it at an optimal level.

Conclusion. For patients with T2DM and concomitant obesity, vitamin D and β-carotene turned out to be the most problematic, since their reduced levels are detected more often than other vitamins. In addition to the optimal blood level of vitamins C and E, it is extremely important for them to maintain the blood molar ratio of ascorbic acid and α-tocopherol at an optimal level. The purposefully development of specialized vitamin complexes containing effective doses is necessary for patients with DN.

Keywords:vitamins; vitamin deficiency; type 2 diabetes mellitus; diabetic nephropathy; polyhypovitaminosis; blood serum

Funding. The research was carried out at the expense of a subsidy for the implementation of the state task (theme No. 0410-2022-0002) without attracting additional funding from third parties.

Conflict of interest. O.A. Vrzhesinskaya is a scientific editor and executive secretary of the editorial office of the journal, the other authors declare no conflicts of interest.

For citation: Vrzhesinskaya O.A., Leonenko S.N., Kodentsova V.M., Beketova N.A., Kosheleva O.V., Pilipenko V.V., Plotnikova O.A., Alekseeva R.I., Sharafetdinov Kh.Kh. Vitamin supply of patients with type 2 diabetes mellitus complicated by nephropathy. Voprosy pitaniia [Problems of Nutrition]. 2022; 91 (2): 58–71. DOI: https://doi.org/10.33029/0042-8833-2022-91-2-58-71 (in Russian)

Литература

1. Podkowińska A., Formanowicz D. Chronic kidney disease as oxidative stress-and inflammatory-mediated cardiovascular disease // Antioxidants (Basel). 2020. Vol. 9, N. 8. P. 752. DOI: https://doi.org/10.3390/antiox9080752

2. GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 // Lancet. 2020. Vol. 395. P. 709–733. DOI: https://doi.org/10.1016/S0140-6736(20)30045-3

3. Tinti F., Lai S., Noce A., Rotondi S., Marrone G., Mazzaferro S. et al. Chronic kidney disease as a systemic inflammatory syndrome: update on mechanisms involved and potential treatment // Life (Basel). 2021. Vol. 11, N 5. P. 419. DOI: https://doi.org/10.3390/life11050419

4. Wang G., Ouyang J., Li S., Wang H., Lian B., Liu Z. et al. The analysis of risk factors for diabetic nephropathy progression and the construction of a prognostic database for chronic kidney diseases // J. Transl. Med. 2019. Vol. 17. P. 264. DOI: https://doi.org/10.1186/s12967-019-2016-y

5. Jankowska M., Rutkowski B., Dębska-Ślizień A. Vitamins and microelement bioavailability in different stages of chronic kidney disease // Nutrients. 2017. Vol. 9, N 3. P. 282. DOI: https://doi.org/10.3390/nu9030282

6. van de Wal-Visscher E.R., Kooman J.P., van der Sande F.M. Magnesium in chronic kidney disease: should we care? // Blood Purif. 2018. Vol. 45, N 1–3. P. 173–178. DOI: https://doi.org/10.1159/000485212

7. Van Kempen T.A., Deixler E. SARS-CoV-2: influence of phosphate and magnesium, moderated by vitamin D, on energy (ATP) metabolism and on severity of COVID-19 // Am. J. Physiol. Endocrinol. Metab. 2021. Vol. 320, N 1. P. E2–E6. DOI: https://doi.org/10.1152/ajpendo.00474.2020

8. Tanaka K., Ao M., Kuwabara A. Insufficiency of B vitamins with its possible clinical implications // J. Clin. Biochem. Nutr. 2020. Vol. 67, N 1. P. 19–25. DOI: https://doi.org/10.3164/jcbn.20-56

9. Adaikalakoteswari A.A., Rabbani N.A., Waspadji S.B., Tjokroprawiro A.C., Kariadi S.H.D., Adam J.M.F.E. et al. Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia – link to renal status, glycemic control and vascular inflammation // Diabetes Res. Clin. Pract. 2012. Vol. 95, N 3. P. 415–424. DOI: https://doi.org/10.1016/j.diabres.2011.10.042

10. Iwakawa H., Nakamura Y., Fukui T., Fukuwatar T., Ugi S., Maegawa H. et al. Concentrations of water-soluble vitamins in blood and urinary excretion in patients with diabetes mellitus // Nutr. Metab. Insights. 2016. Vol. 9. P. 85–92. DOI: https://doi.org/10.4137/NMI.S40595

11. Anwar A., Azmi M.A., Siddiqui J.A., Panhwar G., Shaikh F., Ariff M. Thiamine level in type I and type II diabetes mellitus patients: a comparative study focusing on hematological and biochemical evaluations // Cureus. 2020. Vol. 12, N 5. P. e8027. DOI: https://doi.org/10.7759/cureus.8027

12. Nix W.A., Zirwes R., Bangert V., Kaiser R.P., Schilling M., Hostalek U. et al. Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy // Diabetes Res. Clin. Pract. 2015. Vol. 107, N 1. P. 157–165. DOI: https://doi.org/10.1016/j.diabres.2014.09.058

13. Valdés-Ramos R., Guadarrama-López A.L., Martínez-Carrillo B.E., Benítez-Arciniega A.D. Vitamins and type 2 diabetes mellitus // Endocr. Metab. Immune Disord. Drug Targets. 2015. Vol. 15, N 1. P. 54–63. DOI: https://doi.org/10.2174/1871530314666141111103217

14. Gavrilov V., Harman-Boehm I., Amichay D., Tessler G., Shuster T., Friger M. et al. Kidney function and retinol status in type 2 diabetes mellitus patients // Acta Diabetol. 2012. Vol. 49, N 2. P. 137–143. DOI: https://doi.org/10.1007/s00592-011-0303-z

15. Новикова М.С., Руденко Т.Е., Котяшкова О.М., Анциферов М.Б. Минерально-костные нарушения у пациентов с сахарным диабетом и хронической болезнью почек // Эффективная фармакотерапия. 2013. № 46. С. 46–52.

16. Jean G., Souberbielle J.C., Chazot C. Vitamin D in chronic kidney disease and dialysis patients // Nutrients. 2017. Vol. 9, N 4. P. 328. DOI: https://doi.org/10.3390/nu9040328

17. de Bragança A.C., Canale D., Gonçalves J.G., Shimizu M.H.M., Seguro A.C., Volpini R.A. Vitamin D deficiency aggravates the renal features of moderate chronic kidney disease in 5/6 nephrectomized rats // Front. Med. (Lausanne). 2018. Vol. 5. P. 282. DOI: https://doi.org/10.3389/fmed.2018.00282

18. Delrue C., Speeckaert R., Delanghe J.R., Speeckaert M.M. The role of vitamin D in diabetic nephropathy: a translational approach // Int. J. Mol. Sci. 2022. Vol. 23, N 2. P. 807. DOI: https://doi.org/10.3390/ijms23020807

19. Felício J.S., de Rider Britto H.A., Cortez P.C., de Souza Resende F., de Lemos M.N., De Moraes L.V. et al. Association between 25 (OH) vitamin D, HbA1c and albuminuria in diabetes mellitus: data from a population-based study (VIDAMAZON) // Front. Endocrinol. (Lausanne). 2021. Vol. 12. Article ID 723502. DOI: https://doi.org/10.3389/fendo.2021.723502

20. Gembill G., Cernaro V., Salvo A., Siligato R., Laudani A., Buemi M. et al. Role of vitamin D status in diabetic patients with renal disease // Medicina (Kaunas). 2019. Vol. 55, N 6. P. 273. DOI: https://doi.org/10.3390/medicina55060273

21. Демидова Т.Ю., Лобанова К.Г., Переходов С.Н., Анциферов М.Б., Ойноткинова О.Ш. Клинико-лабораторная характеристика пациентов с COVID-19 и сопутствующим сахарным диабетом 2 типа // Кардиоваскулярная терапия и профилактика. 2021. Т. 20, № 1. С. 47–52. DOI: https://doi.org/10.15829/1728-8800-2021-2750

22. Gonçalves S.E.A.B., Gonçalves T.J.M., Guarnieri A., Risegato R.C., Guimarães M.P., de Freitas D.C. Association between thiamine deficiency and hyperlactatemia among critically ill patients with diabetes infected by SARS-CoV-2 // J. Diabetes. 2021. Vol. 13, N 5. DOI: https://doi.org/10.1111/1753-0407.13156

23. Figueroa-Pizano M.D., Campa-Mada A.C., Carvajal-Millan E., Martinez-Robinson K.G., Chu A.R. The underlying mechanisms for severe COVID-19 progression in people with diabetes mellitus: a critical review // AIMS Public Health. 2021. Vol. 8, N 4. Р. 720–742. DOI: https://doi.org/10.3934/publichealth.2021057

24. Якушина Л.М., Бекетова Н.А., Бендер Е.Д., Харитончик Л.А. Использование методов ВЭЖХ для определения витаминов в биологических жидкостях и пищевых продуктах // Вопросы питания. 1993. № 1. С. 43–48.

25. Kodentsova V., Vrzhesinskaya O., Spirichev V. Fluorometric riboflavin titration in plasma by riboflavin binding apoprotein as a method for vitamin B2 status assessment // Ann. Nutr. Metab. 1995. Vol. 39. P. 355–360. DOI: https://doi.org/10.1159/000177885

26. Коденцова В.М., Харитончик Л.А., Вржесинская О.А., Переверзева О.Г., Блажеевич Н.В., Спиричев В.Б. Уточнение критериев обеспеченности организма витамином С // Вопросы медицинской химии. 1995. Т. 41, № 1. С. 53–57.

27. Коденцова В.М., Вржесинская О.А., Спиричев В.Б. Изменение обеспеченности витаминами взрослого населения Российской Федерации за период 1987–2009 гг. (к 40-летию лаборатории витаминов и минеральных веществ НИИ питания РАМН) // Вопросы питания. 2010. Т. 79, № 3. P. 68–72.

28. Gey K.F. Vitamins E plus C and interacting conutrients required for optimal health // Biofactors. 1998. Vol. 7, N 1–2. P. 143–174. DOI: https://doi.org/10.1002/biof.5520070115

29. Спиричев В.Б., Коденцова В.М., Вржесинская О.А., Бекетова Н.А., Харитончик Л.А., Алексеева И.А. и др. Методы оценки витаминной обеспеченности населения // Учебно-методическое пособие. Москва : Альтекс, 2001. 68 с.

30. Horwitt M.K., Harvey C.C., Dahm C.H., Searcy M.T. Relationship between tocopherol and serum lipid levels for determination of nutritional adequacy // Ann. N. Y. Acad. Sci. 1972. Vol. 203. P. 223–235. DOI: https://doi.org/10.1111/j.1749-6632.1972.tb27878.x

31. Вржесинская О.А., Бекетова Н.А., Кошелева О.В., Коденцова В.М., Шарафетдинов Х.Х. Оценка витаминного статуса пациентов с морбидным ожирением по совокупности признаков оптимальной обеспеченности // Медицинский вестник Северного Кавказа. 2020. Т. 15, № 4. С. 504–509. DOI: https://doi.org/10.14300/mnnc.2020.15118

32. Liyanage P.L.G.C., Lekamwasam S., Weerarathna T.P., Liyanage C. Effect of vitamin D therapy on urinary albumin excretion, renal functions, and plasma renin among patients with diabetic nephropathy: a randomized, double-blind clinical trial // J. Postgrad. Med. 2018. Vol. 64, N 1. P. 10–15. DOI: https://doi.org/10.4103/jpgm.JPGM_ 598_16

33. Zhang Q., Zhang M., Wang H., Sun C., Feng Y., Zhu W. et al. Vitamin D supplementation improves endothelial dysfunction in patients with non-dialysis chronic kidney disease // Int. Urol. Nephrol. 2018. Vol. 50, N 5. P. 923–927. DOI: https://doi.org/10.1007/s11255-018-1829-6

34. Lundwall K., Jacobson S.H., Jörneskog G., Spaak J. Treating endothelial dysfunction with vitamin D in chronic kidney disease: a meta-analysis // BMC Nephrol. 2018. Vol. 19. P. 247. DOI: https://doi.org/10.1186/s12882-018-1042-y

35. Tan G.C.J., Tan S.M.Q., Phang S.C.W., Ng Y.T., Ng E.Y., Ahmad B. et al. Tocotrienol-rich vitamin E improves diabetic nephropathy and persists 6–9 months after washout: a phase IIa randomized controlled trial // Ther. Adv. Endocrinol. Metab. 2019. Vol. 10. Article ID 2042018819895462. DOI: https://doi.org/10.1177/2042018819895462

36. Koay Y.Y., Tan G.C.J., Phang S.C.W., Ho J.I., Chuar P.F., Ho L.S. et al. A phase IIb randomized controlled trial investigating the effects of tocotrienol-rich vitamin E on diabetic kidney disease // Nutrients. 2021. Vol. 13, N 1. P. 258. DOI: https://doi.org/10.3390/nu13010258

37. Szewczyk K., Chojnacka A., Górnicka M. Tocopherols and tocotrienols – bioactive dietary compounds; what is certain, what is doubt? // Int. J. Mol. Sci. 2021. Vol. 22, N 12. P. 6222. DOI: https://doi.org/10.3390/ijms22126222

38. Farvid M.S., Jalali M, Siassi, F. Hosseini M. Comparison of the effects of vitamins and/or mineral supplementation on glomerular and tubular dysfunction in type 2 diabetes // Diabetes Care. 2005. Vol. 28, N 10. P. 2458–2464. DOI: https://doi.org/10.2337/diacare.28.10.2458

39. Коденцова В.М., Рисник Д.В. Микронутриентные метаболические сети и множественный дефицит микронутриентов: обоснование преимуществ витаминно-минеральных комплексов // Микроэлементы в медицине. 2020. Т. 21, № 4. С. 3−20. DOI: https://doi.org/10.19112/2413-6174-2020-21-4-3-20

References

1. Podkowińska A., Formanowicz D. Chronic kidney disease as oxidative stress-and inflammatory-mediated cardiovascular disease. Antioxidants (Basel). 2020; 9 (8): 752. DOI: https://doi.org/10.3390/antiox9080752

2. GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020; 395: 709–33. DOI: https://doi.org/10.1016/S0140-6736(20)30045-3

3. Tinti F., Lai S., Noce A., Rotondi S., Marrone G., Mazzaferro S., et al. Chronic kidney disease as a systemic inflammatory syndrome: update on mechanisms involved and potential treatment. Life (Basel). 2021; 11 (5): 419. DOI: https://doi.org/10.3390/life11050419

4. Wang G., Ouyang J., Li S., Wang H., Lian B., Liu Z., et al. The analysis of risk factors for diabetic nephropathy progression and the construction of a prognostic database for chronic kidney diseases. J Transl Med. 2019; 17: 264. DOI: https://doi.org/10.1186/s12967-019-2016-y

5. Jankowska M., Rutkowski B., Dębska-Ślizień A. Vitamins and microelement bioavailability in different stages of chronic kidney disease. Nutrients. 2017; 9 (3): 282. DOI: https://doi.org/10.3390/nu9030282

6. van de Wal-Visscher E.R., Kooman J.P., van der Sande F.M. Magnesium in chronic kidney disease: should we care? Blood Purif. 2018; 45 (1–3): 173–8. DOI: https://doi.org/10.1159/000485212

7. Van Kempen T.A., Deixler E. SARS-CoV-2: influence of phosphate and magnesium, moderated by vitamin D, on energy (ATP) metabolism and on severity of COVID-19. Am J Physiol Endocrinol Metab. 2021; 320 (1): E2–6. DOI: https://doi.org/10.1152/ajpendo.00474.2020

8. Tanaka K., Ao M., Kuwabara A. Insufficiency of B vitamins with its possible clinical implications. J Clin Biochem Nutr. 2020; 67 (1): 19–25. DOI: https://doi.org/10.3164/jcbn.20-56

9. Adaikalakoteswari A.A., Rabbani N.A., Waspadji S.B., Tjokroprawiro A.C., Kariadi S.H.K.S., Adam J.M.F.E., et al. Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia – link to renal status, glycemic control and vascular inflammation. Diabetes Res Clin Pract. 2012; 95 (3): 415–24. DOI: https://doi.org/10.1016/j.diabres.2011.10.042

10. Iwakawa H., Nakamura Y., Fukui T., Fukuwatar T., Ugi S., Maegawa H., et al. Concentrations of water-soluble vitamins in blood and urinary excretion in patients with diabetes mellitus. Nutr Metab Insights. 2016; 9: 85–92. DOI: https://doi.org/10.4137/NMI.S40595

11. Anwar A., Azmi M.A., Siddiqui J.A., Panhwar G., Shaikh F., Ariff M. Thiamine level in type I and type II diabetes mellitus patients: a comparative study focusing on hematological and biochemical evaluations. Cureus. 2020; 12 (5): e8027. DOI: https://doi.org/10.7759/cureus.8027

12. Nix W.A., Zirwes R., Bangert V., Kaiser R.P., Schilling M., Hostalek U., et al. Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy. Diabetes Res Clin Pract. 2015; 107 (1): 157–65. DOI: https://doi.org/10.1016/j.diabres.2014.09.058

13. Valdés-Ramos R., Guadarrama-López A.L., Martínez-Carrillo B.E., Benítez-Arciniega A.D. Vitamins and type 2 diabetes mellitus. Endocr Metab Immune Disord Drug Targets. 2015; 15 (1): 54–63. DOI: https://doi.org/10.2174/1871530314666141111103217

14. Gavrilov V., Harman-Boehm I., Amichay D., Tessler G., Shuster T., Friger M., et al. Kidney function and retinol status in type 2 diabetes mellitus patients. Acta Diabetol. 2012; 49 (2): 137–43. DOI: https://doi.org/10.1007/s00592-011-0303-z

15. Novikova M.S., Rudenko T.E., Kotyashkova O.M., Antsiferov M.B. Mineral and bone disorders in patients with diabetes mellitus and chronic kidney disease. Effektivnaya farmakoterapiya [Effective Pharmacotherapy]. 2013. (46): 46–52. (in Russian)

16. Jean G., Souberbielle J.C., Chazot C. Vitamin D in chronic kidney disease and dialysis patients. Nutrients. 2017; 9 (4): 328. DOI: https://doi.org/10.3390/nu9040328

17. de Bragança A.C., Canale D., Gonçalves J.G., Shimizu M.H.M., Seguro A.C., Volpini R.A. Vitamin D deficiency aggravates the renal features of moderate chronic kidney disease in 5/6 nephrectomized rats. Front Med (Lausanne). 2018; 5: 282. DOI: https://doi.org/10.3389/fmed.2018.00282

18. Delrue C., Speeckaert R., Delanghe J.R., Speeckaert M.M. The role of vitamin D in diabetic nephropathy: a translational approach. Int J Mol Sci. 2022; 23 (2): 807. DOI: https://doi.org/10.3390/ijms23020807

19. Felício J.S., de Rider Britto H.A., Cortez P.C., de Souza Resende F., de Lemos M.N., De Moraes L.V., et al. Association between 25 (OH) vitamin D, HbA1c and albuminuria in diabetes mellitus: data from a population-based study (VIDAMAZON). Front Endocrinol (Lausanne). 2021; 12: 723502. DOI: https://doi.org/10.3389/fendo.2021.723502

20. Gembill G., Cernaro V., Salvo A., Siligato R., Laudani A., Buemi M., et al. Role of vitamin D status in diabetic patients with renal disease. Medicina (Kaunas). 2019; 55 (6): 273. DOI: https://doi.org/10.3390/medicina55060273

21. Demidova T.Yu., Lobanova K.G., Perekhodov S.N., Antsiferov M.B., Oynotkinova O.S. Clinical and laboratory characteristics of patients with COVID-19 and concomitant type 2 diabetes. Kardiovaskulyarnaya terapiya i profilaktika [Cardiovascular Therapy and Prevention]. 2021; 20 (1): 47–52. DOI: https://doi.org/10.15829/1728-8800-2021-2750 (in Russian)

22. Gonçalves S.E.A.B., Gonçalves T.J.M., Guarnieri A., Risegato R.C., Guimarães M.P., de Freitas D.C. Association between thiamine deficiency and hyperlactatemia among critically ill patients with diabetes infected by SARS-CoV-2. J Diabetes. 2021; 13 (5). DOI: https://doi.org/10.1111/1753-0407.13156

23. Figueroa-Pizano M.D., Campa-Mada A.C., Carvajal-Millan E., Martinez-Robinson K.G., Chu A.R. The underlying mechanisms for severe COVID-19 progression in people with diabetes mellitus: a critical review. AIMS Public Health. 2021; 8 (4): 720–42. DOI: https://doi.org/10.3934/publichealth.2021057

24. Yakushina L.M., Beketova N.A., Bender E.D., Kharitonchik L.A. Methods of high-performance liquid chromatography for determining vitamin levels in biologic fluids and food products. Voprosy pitaniia [Problems of Nutrition]. 1993; (1): 43–8. (in Russian)

25. Kodentsova V., Vrzhesinskaya O., Spirichev V. Fluorometric riboflavin titration in plasma by riboflavin binding apoprotein as a method for vitamin B2 status assessment. Ann Nutr Metab. 1995; 39: 355–60. DOI: https://doi.org/10.1159/000177885

26. Kodentsova V.M., Kharitonchik L.A., Vrzhesinskaia O.A., Pereverzeva O.G., Blazheevich N.V., Spirichev V.B. Refining criteria for supplying the body with vitamin C. Voprosy meditsinskoy khimii [Problems of Medical Chemistry]. 1995; 41 (1): 53–7. (in Russian)

27. Kodentsova V.M., Vrzhesinskaya O.A., Spirichev V.B. The alteration of vitamin status of adult population of the Russian Federation in 1987–2009 (to the 40th anniversary of the Laboratory of vitamins and minerals of Institute of Nutrition at Russian Academy of Medical Sciences). Voprosy pitaniia [Problems of Nutrition]. 2010; 79 (3): 68–72. (in Russian)

28. Gey K.F. Vitamins E plus C and interacting conutrients required for optimal health. Biofactors. 1998; 7 (1–2): 143–74. DOI: https://doi.org/10.1002/biof.5520070115

29. Spirichev V.B., Kodentsova V.M., Vrzhesinskaya O.A., Beketova N.A., Kharitonchik L.A., Alekseeva I.A., et al. Methods for evaluation of vitamin status: Training handbook. Moscow: Al’teks, 2001: 68 p. (in Russian)

30. Horwitt M.K., Harvey C.C., Dahm C.H., Searcy M.T. Relationship between tocopherol and serum lipid levels for determination of nutritional adequacy. Ann N Y Acad Sci. 1972; 203: 223–35. DOI: https://doi.org/10.1111/j.1749-6632.1972.tb27878.x

31. Vrzhesinskaya O.A., Beketova N.A., Kosheleva O.V., Kodentsova V.M., Sharafetdinov Kh.Kh. Evaluation of vitamin status of patients with morbid obesity by the complex of optimal sufficiency criteria. Meditsinskiy vestnik Severnogo Kavkaza [Medical Bulletin of North Caucasus]. 2020; 15 (4): 504–9. DOI: https://doi.org/10.14300/mnnc.2020.15118 (in Russian)

32. Liyanage P.L.G.C., Lekamwasam S., Weerarathna T.P., Liyanage C. Effect of vitamin D therapy on urinary albumin excretion, renal functions, and plasma renin among patients with diabetic nephropathy: a randomized, double-blind clinical trial. J Postgrad Med. 2018; 64 (1): 10–5. DOI: https://doi.org/10.4103/jpgm.JPGM_598_16

33. Zhang Q., Zhang M., Wang H., Sun C., Feng Y., Zhu W., et al. Vitamin D supplementation improves endothelial dysfunction in patients with non-dialysis chronic kidney disease. Int Urol Nephrol. 2018; 50 (5): 923–7. DOI: https://doi.org/10.1007/s11255-018-1829-6

34. Lundwall K., Jacobson S.H., Jörneskog G., Spaak J. Treating endothelial dysfunction with vitamin D in chronic kidney disease: a meta-analysis. BMC Nephrol. 2018; 19: 247. DOI: https://doi.org/10.1186/s12882-018-1042-y

35. Tan G.C.J., Tan S.M.Q., Phang S.C.W., Ng Y.T., Ng E.Y., Ahmad B., et al. Tocotrienol-rich vitamin E improves diabetic nephropathy and persists 6–9 months after washout: a phase IIa randomized controlled trial. Ther Adv Endocrinol Metab. 2019; 10: 2042018819895462. DOI: https://doi.org/10.1177/2042018819895462

36. Koay Y.Y., Tan G.C.J., Phang S.C.W., Ho J.I., Chuar P.F., Ho L.S., et al. A phase IIb randomized controlled trial investigating the effects of tocotrienol-rich vitamin E on diabetic kidney disease. Nutrients. 2021; 13 (1): 258. DOI: https://doi.org/10.3390/nu13010258

37. Szewczyk K., Chojnacka A., Górnicka M. Tocopherols and tocotrienols – bioactive dietary compounds; what is certain, what is doubt? Int J Mol Sci. 2021; 22 (12): 6222. DOI: https://doi.org/10.3390/ijms22126222

38. Farvid M.S., Jalali M, Siassi, F. Hosseini M. Comparison of the effects of vitamins and/or mineral supplementation on glomerular and tubular dysfunction in type 2 diabetes. Diabetes Care. 2005; 28 (10): 2458–64. DOI: https://doi.org/10.2337/diacare.28.10.2458

39. Kodentsova V.M., Risnik D.V Micronutrient metabolic networks and multiple micronutrient deficiency: a rationale for the advantages of vitamin-mineral supplements. Mikroelementy v meditsine [Trace Elements in Medicine]. 2020; 21 (4): 3−20. DOI: https://doi.org/10.19112/2413-6174-2020-21-4-3-20 (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Viktor A. Tutelyan
Full Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Scientific Director of the Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia)

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