Adequate and clinically effective levels of curcumin consumption

Abstract

Despite the existence of sufficiently effective drug therapy, interest in additional dietary interventions that improve the clinical condition of patients with the most common alimentary diseases is constantly growing; as well as the inclusion of biologically active compounds (BAC) of plant origin as functional ingredients in foods for special dietary uses (FSDU) and dietary supplements is intensively developing.

The purpose of the review is comparison of curcumin doses allowed for use in dietary supplements and FSDU with doses that provide a clinical effect, as well as an analysis of ways to increase curcumin bioavailability.

Material and methods. A review of the existing literature on the problem in recent years was carried out using the databases of the Russian Science Citation Index, PubMed, ResearchGate.

Results. The amount of BAC added to the FSDU in the daily portion has been established by domestic regulatory documents. The allowed maximum level in FSDU for curcumin is 150 mg per day. Literature analysis has shown that effective doses of turmeric are 320–1670 mg per day when consumed for 10–12 weeks. The main barriers for using curcumin at lower doses are its low water solubility, rapid metabolism and elimination from the body, and therefore poor bioavailability. Curcumin bioavailability can be increased by including it in liposomes, phospholipid complexes, emulsions, oleogels, hydrogels, etc.

Conclusion. Curcumin content in FSDU in an amount that does not reach doses with efficacy proven in a certain pathology, and the inclusion of such FSDU in the diet for a short period does not allow to achieve the expected result. A promising approach to achieve a clinical effect at lower doses of curcumin is the use of new technological methods to increase bioavailability.

Keywords:curcumin; oleogels; foods for special dietary uses; dietary supplements; clinical efficacy; bioavailability

Funding. The research was supported by Russian science foundation (No. 19-16-00113).

Conflict of interest. The authors declare no conflicts of interest.

Contribution. The concept and design of the study – Kodentsova V.M.; collection, analysis of the material – Risnik D.V.; writing the text – Kodentsova V.M., Sarkisyan V.A.; editing – Kodentsova V.M., Sarkisyan V.A., Frolova Yu.V.; approval of the final version of the article, responsibility for the integrity of all parts of the article – all authors.

For citation: Kodentsova V.M., Risnik D.V., Sarkisyan V.A., Frolova Yu.V. Adequate and clinically effective levels of curcumin consumption. Voprosy pitaniia [Problems of Nutrition]. 2022; 91 (5): 6–15. DOI: https://doi.org/10.33029/0042-8833-2022-91-5-6-15 (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Viktor A. Tutelyan
Full Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Scientific Director of the Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia)

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