References
1. Head K.A., Kelly G.S. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Altern Med Rev. 2009; 14 (2): 114–40.
2. Özdemir Z., Bildziukevich U., Wimmerová M., Macůrková A., Lovecká P., Wimmer Z. Plant adaptogens: natural medicaments for 21st century? ChemistrySelect. 2018; 3: 2196–214. DOI: https://doi.org/10.1002/slct.201702682
3. Das N., Mishra S.K., Bishayee A., Ali E.S., Bishayee A. The phytochemical, biological, and medicinal attributes of phytoecdysteroids: an updated review. Acta Pharm Sin B. 2021; 11 (7): 1740–66. DOI: https://doi.org/10.1016/j.apsb.2020.10.012
4. Ren G., Teng C., Fan X., Guo S., Zhao G., Zhang L., et al. Nutrient composition, functional activity and industrial applications of quinoa (Chenopodium quinoa Willd.). Food Chem. 2023; 410: 135290. DOI: https://doi.org/10.1016/j.foodchem.2022.135290
5. Shahbaz M., Raza N., Islam M., Imran M., Ahmad I., Meyyazhagan A., et al. The nutraceutical properties and health benefits of pseudocereals: a comprehensive treatise. Crit Rev Food Sci Nutr. 2023; 63 (29): 10 217–29. DOI: https://doi.org/10.1080/10408398.2022.2071205
6. Filho A.M., Pirozi M.R., Borges J.T., Pinheiro Sant’Ana H.M., Chaves J.B., Coimbra J.S. Quinoa: nutritional, functional, and antinutritional aspects. Crit Rev Food Sci Nutr. 2017; 57 (8): 1618–30. DOI: https://doi.org/10.1080/10408398.2014.1001811
7. Li Y., Feng Z., Wu T., You H., Wang W., Liu X., et al. Quinoa peptides alleviate obesity in mice induced by a high-fat diet via regulating of the PPAR-α/γ signaling pathway and gut microbiota. Mol Nutr Food Res. 2023; 67 (22): e2300258. DOI: https://doi.org/10.1002/mnfr.202300258
8. Ng C.Y., Wang M. The functional ingredients of quinoa (Chenopodium quinoa) and physiological effects of consuming quinoa: a review. Food Front. 2021; 2: 329–56. DOI: https://doi.org/10.1002/fft2.109
9. Zorin S.N., Petrov N.A., Bokov D.O., Bessonov V.V. Quinoa grains (Chenopodium quinoa Willd.) – a source of protein and biologically active substances. Res J Pharm Technol. 2021; 14 (11): 5781–4. DOI: https://doi.org/10.52711/0974-360X.2021.01005
10. Liu Y., Liu J., Kong Z., Huan X., Li L., Zhang P., et al. Transcriptomics and metabolomics analyses of the mechanism of flavonoid synthesis in seeds of differently colored quinoa strains. Genomics. 2022; 114 (1): 138–48. DOI: https://doi.org/10.1016/j.ygeno.2021.11.030
11. Lin M., Han P., Li Y., Wang W., Lai D., Zhou L. Quinoa secondary metabolites and their biological activities or functions. Molecules. 2019; 24 (13): 2512. DOI: https://doi.org/10.3390/molecules24132512
12. Liu P.J., Hu Y.S., Wang M.J., Kang L. Nutrient weight against sarcopenia: regulation of the IGF-1/PI3K/Akt/FOXO pathway in quinoa metabolites. Curr Opin Pharmacol. 2021; 61: 136–41. DOI: https://doi.org/10.1016/j.coph.2021.10.001
13. Yoon B.H., Jung J.W., Lee J.J., Cho Y.W., Jang C.G., Jin C., et al. Anxiolytic-like effects of sinapic acid in mice. Life Sci. 2007; 81 (3): 234–40. DOI: https://doi.org/10.1016/j.lfs.2007.05.007
14. Franco R.R., de Almeida Takata L., Chagas K., Justino A.B., Saraiva A.L., Goulart L.R., et al. A 20-hydroxyecdysone-enriched fraction from Pfaffia glomerata (Spreng.) pedersen roots alleviates stress, anxiety, and depression in mice. J Ethnopharmacol. 2021; 267: 113599. DOI: https://doi.org/10.1016/j.jep.2020.113599
15. Sidorova Y.S., Shipelin V.A., Petrov N.A., Zorin S.N., Mazo V.K. Anxiolytic and antioxidant effect of phytoecdysteroids and polyphenols from Chenopodium quinoa on an in vivo restraint stress model. Molecules. 2022; 27 (24): 9003. DOI: https://doi.org/10.3390/molecules27249003
16. Dougherty J.P., Springer D.A., Gershengorn M.C. The treadmill fatigue test: a simple, high-throughput assay of fatigue-like behavior for the mouse. J Vis Exp. 2016; 111: 54052. DOI: https://doi.org/10.3791/54052
17. Zorin S.N., Sidorova Yu.S., Petrov N.A., Perova I.B., Malinkin A.D., Bokov D.O., et al. A new functional food ingredient enriched by Phytoecdisteroids and Polyphenols from quinoa grains (Chenopodium quinoa Willd.). Res J Pharm Technol. 2021; 14 (8): 4321–8. DOI: https://doi.org/10.52711/0974-360X.2021.00750
18. Reeves P.G. Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr. 1997; 127 (5 suppl): 838S–41S. DOI: https://doi.org/10.1093/jn/127.5.838s
19. Committee for the Update of the Guide for the Care and Use of Laboratory animals. Guide Laboratory for the Care and Use of Animals. Washington, DC: National Academies Press (US), 2011. ISBN 978-0-309-15400-0.
20. Sharanova N.E., Kirbaeva N.V., Toropygin I.Y., Khryapova E.V., Koplik E.V., Soto C.K., et al. Effect of acute emotional stress on proteomic profile of selected brain areas and lysosomal proteolysis in rats with different behavioral activity. Bull Exp Biol Med. 2016; 161: 355–8. DOI: https://doi.org/10.1007/s10517-016-3413-3
21. Apryatin S.A., Shipelin V.A., Trusov N.V., Mzhelskaya K.V., Evstratova V.S., Kirbaeva N.V., et al. Comparative analysis of the influence of a high-fat/high-carbohydrate diet on the level of anxiety and neuromotor and cognitive functions in Wistar and DAT-KO rats. Physiol Rep. 2019; 7: e13987. DOI: https://doi.org/10.14814/phy2.13987
22. de Souza R.F., Augusto R.L., de Moraes S.R.A., de Souza F.B., Gonçalves L.V.D.P., Pereira D.D., et al. Ultra-endurance associated with moderate exercise in rats induces cerebellar oxidative stress and impairs reactive GFAP isoform profile. Front Mol Neurosci. 2020; 13: 157. DOI: https://doi.org/10.3389/fnmol.2020.00157
23. Dinan L., Dioh W., Veillet S., Lafont R. 20-hydroxyecdysone, from plant extracts to clinical use: therapeutic potential for the treatment of neuromuscular, cardio-metabolic and respiratory diseases. Biomedicines. 2021; 9 (5): 492. DOI: https://doi.org/10.3390/biomedicines9050492
24. Apryatin S.A., Shipelin V.A., Sidorova Y.S., Petrov N.A., Gmoshinskii I.V., Nikityuk D.B. Interspecific differences in behavioral responses and neuromotorics between laboratory rodents receiving rations with easily digested carbohydrates. Bull Exp Biol Med. 2018; 165 (1): 5–9. DOI: https://doi.org/10.1007/s10517-018-4086-x
25. Mzhelskaya K.V., Shipelin V.A., Shumakova A.A., Musaeva A.D., Soto J.S., Riger N.A., et al. Effects of quercetin on the neuromotor function and behavioral responses of Wistar and Zucker rats fed a high-fat and high-carbohydrate diet. Behav Brain Res. 2020; 378: 112270. DOI: https://doi.org/10.1016/j.bbr.2019.112270
26. Foright R.M., Johnson G.C., Kahn D., Charleston C.A., Presby D.M., Bouchet C.A., et al. Compensatory eating behaviors in male and female rats in response to exercise training. Am J Physiol Regul Integr Comp Physiol. 2020; 319 (2): R171–83. DOI: https://doi.org/10.1152/ajpregu.00259.2019
27. Erta M., Quintana A., Hidalgo J. Interleukin-6, a major cytokine in the central nervous system. Int J Biol Sci. 2012; 8 (9): 1254–66. DOI: https://doi.org/10.7150/ijbs.4679
28. Voytenko N.G. Variability of biochemical blood parameters and establishment of reference intervals in preclinical studies. Report 1: rats. Laboratornye zhivotnye dlya nauchnykh issledovaniy [Laboratory Animals for Scientific Research]. 2020; (1): 1–6. DOI: https://doi.org/10.29296/2618723X-2020-01-06 (in Russian)
29. Chen S., Minegishi Y., Hasumura T., Shimotoyodome A., Ota N. Involvement of ammonia metabolism in the improvement of endurance performance by tea catechins in mice. Sci Rep. 2020; 10: 6065. DOI: https://doi.org/10.1038/s41598-020-63139-9
30. Qaddumi W.N., Jose P.A. The role of the renal dopaminergic system and oxidative stress in the pathogenesis of hypertension. Biomedicines. 2021; 9 (2): 139. DOI: https://doi.org/10.3390/biomedicines9020139
31. Feng Y., Yan X., Guo F., Wang S., Liu Z., Long W. Identification, expression analysis of quinoa betalain biosynthesis genes and their role in seed germination and cold stress. Plant Signal Behav. 2023; 18 (1): 2250891. DOI: https://doi.org/10.1080/15592324.2023.2250891
32. Jan N., Hussain S.Z., Naseer B., Bhat T.A. Amaranth and quinoa as potential nutraceuticals: a review of anti-nutritional factors, health benefits and their applications in food, medicinal and cosmetic sectors. Food Chem. 2023; 18: 100687 DOI: https://doi.org/10.1016/j.fochx.2023.100687