Innovative methods for extracting biolactive сompounds from plant materials

Abstract

Modern methods for extracting bioactive сompounds (BAC) from various raw materials are focused on efficacy and environmental awareness, involve the use of mathematical and statistical optimization methods, the choice of green solvents, and the use of additive extraction technology.

The aim of this review was to present and briefly discuss up-to-date information on modern technological approaches to the production of plant BAС extracts for applying in food ingredients and foods for special dietary uses.

Material and methods. For the main search of sources, the PubMed bibliographic database, Scopus and Web of Science databases, and the Google Scholar search engine were used. The search depth was 15 years.

Results. The article presents a brief review of modern approaches to the extraction, concentration and purification of polyphenolic compounds from various plant materials. As an additive extraction technology aimed at destroying/increasing the permeability of the plant cell wall, a wide range of physical methods has been successfully used: ultrasound, microwave radiation, homogenization, application of a pulsed electric field, high hydrostatic pressure, cryo-crushing. A brief description of each method, its advantages and disadvantages are presented. Improving food safety and compliance with environmental regulations requires the choice of a safe, environmentally friendly and yet efficient extraction process. For these purposes enzymatic extraction, environmentally friendly solvents, such as deep eutectic solvents, supercritical fluid extraction and membrane technology are successfully used. The use of mathematical and statistical methods can reduce the total number of experimental trials and reduce the cost and time of experiments. The use of these methods together makes it possible to vary deliberately the process parameters in relation to a specific plant material and the final product, which provides the opportunity to isolate BAS concentrates from plant raw materials with a high yield.

Conclusion. The introduction of innovative technological approaches for obtaining extracts of BAC of plant origin determines the prospects for the production of a wide range of foods for special dietary uses that meet high safety and efficiency requirements.

Keywords:bioactive сompounds; plant raw materials; extraction; polyphenols; assisting extraction technologies; foods for special dietary uses; safety

Funding. The research was carried out with funding from the Russian Science Foundation (grant No. 19-16-00107-P), https://rscf.ru/project/22-16-35008/.

Conflict of interest. The authors declare no conflicts of interest.

Contribution. The concept and design of the study – all authors; the collection of material – all authors; writing the text – Sidorova Yu.S., Mazo V.K.; editing, approval of the final version of the article, responsibility for the integrity of all parts of the article – all authors.

For citation: Sidorova Yu.S., Petrov N.A., Zorin S.N., Mazo V.K. Innovative methods for extracting biolactive сompounds from plant materials. Voprosy pitaniia [Problems of Nutrition]. 2023; 92 (6): 28–37. DOI: https://doi.org/10.33029/0042-8833-2023-92-6-28-37 (in Russian)

References

1. Konichev A.S., Baurin P.V., Fedorovsky N.N., Marakhova A.I., Yakubovich L.M., Chernikova M.A. Traditional and modern methods of extraction of biologically active substances from plant materials: prospects, advantages, disadvantages. Vestnik Moskovskogo gosudarstvennogo oblastnogo universiteta. Seriya: Estestvennye nauki [Bulletin of the Moscow State Regional University. Series: Natural Sciences]. 2011; (3): 49–54. (in Russian)

2. Aslanova G.I. Methods for extracting biologically active substances from plant materials. Alleya nauki [Science Alley]. 2017; 4 (10): 220–3. (in Russian)

3. Savic I.M., Savic Gajic I.M. Optimization of ultrasound-assisted extraction of polyphenols from wheatgrass (Triticum aestivum L.). J Food Sci Technol. 2020; 57 (8): 2809–18. DOI: https://doi.org/10.1007/s13197-020-04312-w

4. Savic Gajic I.M., Savic I.M., Gajic D.G., Dosic A. Ultrasound-assisted extraction of carotenoids from orange peel using olive oil and its encapsulation in Ca-alginate beads. Biomolecules. 2021; 11 (2): 225. DOI: https://doi.org/10.3390/biom11020225

5. Cui Q., Peng X., Yao X.H., Wei Z.F., Luo M., Wang W., et al. Deep eutectic solvent-based microwave-assisted extraction of genistin, genistein and apigenin from pigeon pea roots. Sep Purif Technol. 2015; 150: 63–72. DOI: https://doi.org/10.1016/j.seppur.2015.06.026

6. Cvjetko Bubalo M., Ćurko N., Tomašević M., Kovačević Ganić K., Radojčić Redovniković I. Green extraction of grape skin phenolics by using deep eutectic solvents. Food Chem. 2016; 200:159–66. DOI: https://doi.org/10.1016/j.foodchem.2016.01.040

7. Silva M.O., Honfoga J.N.B., Medeiros L.L., Madruga M.S., Bezerra T.K.A. Obtaining bioactive compounds from the coffee husk (Coffea arabica L.) using different extraction methods. Molecules. 2020; 26 (1): 46. DOI: https://doi.org/10.3390/molecules26010046

8. Kumar K., Srivastav S., Sharanagat V.S. Ultrasound assisted extraction (UAE) of bioactive compounds from fruit and vegetable processing by-products: a review. Ultrason Sonochem. 2021; 70: 105325. DOI: https://doi.org/10.1016/j.ultsonch.2020.105325

9. Bhagya Raj G.V.S., Dash K.K. Ultrasound-assisted extraction of phytocompounds from dragon fruit peel: optimization, kinetics and thermodynamic studies. Ultrason Sonochem. 2020; 68: 105180. DOI: https://doi.org/10.1016/j.ultsonch.2020.105180

10. Xue H., Tan J., Li Q., Tang J., Cai X. Ultrasound-assisted deep eutectic solvent extraction of anthocyanins from blueberry wine residues: optimization, identification, and HepG2 antitumor activity. Molecules. 2020; 25 (22): 5456. DOI: https://doi.org/10.3390/molecules25225456

11. Samarova A.A., Shishaeva L.M., Toykka A.M. Phase equilibria and extraction properties of deep eutectic solvents in alcohol–ether systems. Teoreticheskie osnovy khimicheskoy tekhnologii [Theoretical Foundations of Chemical Technology]. 2020; 54 (4): 421–30. DOI: https://doi.org/10.31857/S0040357120040132 (in Russian)

12. Xie P., Huang L., Zhang C., Deng Y., Wang X., Cheng J. Enhanced extraction of hydroxytyrosol, maslinic acid and oleanolic acid from olive pomace: process parameters, kinetics and thermodynamics, and greenness assessment. Food Chem. 2019; 276: 662–74. DOI: https://doi.org/10.1016/j.foodchem.2018.10.079

13. Tapia-Quirós P., Montenegro-Landívar M.F., Reig M., Vecino X., Alvarino T., Cortina J.L., et al. Olive mill and winery wastes as viable sources of bioactive compounds: a study on polyphenols recovery. Antioxidants (Basel). 2020; 9 N 11. P. 1074. DOI: https://doi.org/10.3390/antiox9111074

14. Chanioti S., Katsouli M., Tzia C. Novel processes for the extraction of phenolic compounds from olive pomace and their protection by encapsulation. Molecules. 2021; 26 (6): 1781. DOI: https://doi.org/10.3390/molecules26061781

15. Kaukhova I., Weinstein V., Burakova M., Aroyan M., Novikova E. Methods of extraction of medicinal vegetable raw materials in phytosubstances technology. In: Advances in Biological Sciences Research. 1st International Symposium Innovations in Life Sciences (ISILS 2019). 2019; 7: 140–2.

16. Vieira V., Prieto M.A., Barros L., Coutinho J.A.P., Ferreira O., Ferreira I.C.F.R. Optimization and comparison of maceration and microwave extraction systems for the production of phenolic compounds from Juglans regia L. for the valorization of walnut leaves. Ind Crops Prod. 2017; 107: 341–52. DOI: https://doi.org/10.1016/j.indcrop.2017.06.012

17. Li C., Zhang J., Zhao C., Yang L., Zhao W., Jiang H., et al. Separation of the main flavonoids and essential oil from seabuckthorn leaves by ultrasonic/microwave-assisted simultaneous distillation extraction. R Soc Open Sci. 2018; 5 (7): 180133. DOI: https://doi.org/10.1098/rsos.180133

18. Nowacka M., Tappi S., Wiktor A., Rybak K., Miszczykowska A., Czyzewski J., et al. The impact of pulsed electric field on the extraction of bioactive compounds from beetroot. Foods. 2019; 8 (7): 244. DOI: https://doi.org/10.3390/foods8070244

19. Tylewicz U., Tappi S., Mannozzi C., Romani S., Dellarosa N., Laghi L., et al. Effect of pulsed electric field (PEF) pre-treatment coupled with osmotic dehydration on physico-chemical characteristics of organic strawberries. J Food Eng. 2017; 213: 2–9. DOI: https://doi.org/10.1016/j.jfoodeng.2017.04.028

20. Barba F.J., Parniakov O., Pereira S.A., Wiktor A., Grimi N., Boussetta N., et al. Current applications and new opportunities for the use of pulsed electric fields in food science and industry. Food Res Int. 2015; 77 (4): 773–98. DOI: https://doi.org/10.1016/j.foodres.2015.09.015

21. Ahmad Shiekh K., Odunayo Olatunde O., Zhang B., Huda N., Benjakul S. Pulsed electric field assisted process for extraction of bioactive compounds from custard apple (Annona squamosa) leaves. Food Chem. 2021; 359: 129976. DOI: https://doi.org/10.1016/j.foodchem.2021.129976

22. El Kantar S., Boussetta N., Lebovka N., Foucart F., Rajha H.N., Maroun R.G., et al. Pulsed electric field treatment of citrus fruits: improvement of juice and polyphenols extraction. Innov Food Sci Emerg Technol. 2018; 46: 153–61. DOI: https://doi.org/10.1016/j.ifset.2017.09.024

23. Maza M.A., Martínez J.M., Delso C., Camargo A., Raso J., Álvarez I. PEF-dependency on polyphenol extraction during maceration/fermentation of Grenache grapes. Innov Food Sci Emerg Technol. 2020; 60: 102303. DOI: https://doi.org/10.1016/j.ifset.2020.102303

24. Navarro-Baez J.E., Martínez L.M., Welti-Chanes J., Buitimea-Cantúa G.V., Escobedo-Avellaneda Z. High hydrostatic pressure to increase the biosynthesis and extraction of phenolic compounds in food: a review. Molecules. 2022; 27 (5): 1502. DOI: https://doi.org/10.3390/molecules27051502

25. Martín J., Asuero A.G. High hydrostatic pressure for recovery of anthocyanins: effects, performance, and applications. Sep Purif Rev. 2021; 50 (2): 159–76. DOI: https://doi.org/10.1080/15422119.2019.1632897

26. Ma J., Yang H., Chen Y., Feng X., Wu C., Long F. Purified saponins in Momordica charantia treated with high hydrostatic pressure and ionic liquid-based aqueous biphasic systems. Foods. 2022; 11 (13): 1930. DOI: https://doi.org/10.3390/foods11131930

27. Prasad N., Yang B., Zhao M., Wei X., Jiang Y., Chen F. High pressure extraction of corilagin from longan (Dimocarpus longan Lour.) fruit pericarp. Sep Purif Technol. 2009; 70 (1): 41–5. DOI: https://doi.org/10.1016/j.seppur.2009.08.009

28. Okur I., Baltacıoğlu C., Ağçam E., Baltacıoğlu H., Alpas H. Evaluation of the effect of different extraction techniques on sour cherry pomace phenolic content and antioxidant activity and determination of phenolic compounds by FTIR and HPLC. Waste Biomass Valor. 2019; 10: 3545–55. DOI: https://doi.org/10.1007/s12649-019-00771-1

29. Cascaes Teles A.S., Hidalgo Chávez D.W., Zarur Coelho M.A., Rosenthal A., Fortes Gottschalk L.M., Tonon R.V. Combination of enzyme-assisted extraction and high hydrostatic pressure for phenolic compounds recovery from grape pomace. J Food Eng. 2021; 288: 110128. DOI: https://doi.org/10.1016/j.jfoodeng.2020.110128

30. Berestova A.V., Zinyukhin G.B., Maneeva E.Sh. Features of cryoprocessing of plant raw materials. Vestnik Orenburgskogo gosudarstvennogo universiteta [Bulletin of the Orenburg State University]. 2015; 184 (9): 130–6. (in Russian)

31. Conidi C., Drioli E., Cassano A. Coupling ultrafiltration-based processes to concentrate phenolic compounds from aqueous Goji berry extracts. Molecules. 2020; 25 (16): 3761. DOI: https://doi.org/10.3390/molecules25163761

32. Zu Y., Wang Y., Fu Y., Li S., Sun R., Liu W., Luo H. Enzyme-assisted extraction of paclitaxel and related taxanes from needles of Taxus chinensis. Sep Purif Technol. 2009; 68 (2): 238–43. DOI: https://doi.org/10.1016/J.SEPPUR.2009.05.009

33. Ma X.D., Zhang X.G., Guo S.J., Ma G.Y., Liu W.J., Wang N., et al. Application of enzyme-assisted extraction of baicalin from Scutellaria baicalensis Georgi. Prep Biochem Biotechnol. 2021; 51 (3): 241–51. DOI: https://doi.org/10.1080/10826068.2020.1808791

34. Pimentel M.R., Molina G., Dionísio A.P., Maróstica Junior M.R., Pastore G.M. The use of endophytes to obtain bioactive compounds and their application in biotransformation process. Biotechnol Res Int. 2011; 2011: 576286. DOI: https://doi.org/10.4061/2011/576286

35. Su C.H., Pham T.T.T., Cheng H.H. Aqueous enzymatic extraction of rosmarinic acid from Salvia officinalis: optimisation using response surface methodology. Phytochem Anal. 2020; 31 (5): 575–82. DOI: https://doi.org/10.1002/pca.2922

36. Kostyleva E.V., Sereda A.S., Velikoretskaya I.A., Kurbatova E.I., Tsurikova N.V. Use of proteolytic enzymes to obtain protein hydrolysates for food use from recycled materials. Voprosy pitaniia [Problems of Nutrition]. 2023; 92 (1): 116–32. DOI: https://doi.org/10.33029/0042-8833-2023-92-1-116-132 (in Russian)

37. Wei Z., Qi X., Li T., Luo M., Wang W., Zu Y., et al. Application of natural deep eutectic solvents for extraction and determination of phenolics in Cajanus cajan leaves by ultra performance liquid chromatography. Sep Purif Technol. 2015; 149: 237–44. DOI: https://doi.org/10.1016/j.seppur.2015.05.015

38. Huang Y., Feng F., Jiang J., Qiao Y., Wu T., Voglmeir J., et al. Green and efficient extraction of rutin from tartary buckwheat hull by using natural deep eutectic solvents. Food Chem. 2016; 221: 1400–7. DOI: https://doi.org/10.1016/j.foodchem.2016.11.013

39. Chanioti S., Tzia C. Extraction of phenolic compounds from olive pomace by using natural deep eutectic solvents and innovative extraction techniques. Innov Food Sci Emerg Technol. 2018; 48: 228–39. DOI: https://doi.org/10.1016/j.ifset.2018.07.001

40. García A., Rodríguez-Juan E., Rodríguez-Gutiérrez G., Rios J., Fernández-Bolaños J. Extraction of phenolic compounds from virgin olive oil by deep eutectic solvents (DESs). Food Chem. 2016; 197: 554–61. DOI: https://doi.org/10.1016/j.foodchem.2015.10.131

41. Bader C.D., Neuber M., Panter F., Krug D., Müller R. Supercritical fluid extraction enhances discovery of secondary metabolites from myxobacteria. Anal Chem. 2020; 92 (23): 15 403–11. DOI: https://doi.org/10.1021/acs.analchem.0c02995

42. Khaw K.Y., Parat M.O., Shaw P.N., Falconer J.R. Solvent supercritical fluid technologies to extract bioactive compounds from natural sources: a review. Molecules. 2017; 22 (7): 1186. DOI: https://doi.org/10.3390/molecules22071186

43. Kas’yanov G.I. Technique and technology for the use of carbon dioxide in the sub- and supercritical state. Vestnik VGUIT [Bulletin of VGUIT]. 2014; (1): 130–5. (in Russian)

44. Kas’yanov G.I. Extraction capabilities of carbon dioxide in the sub- and supercritical state. Nauka. Tekhnika. Tekhnologii (politekhnicheskiy vestnik) [Science. Technique. Technologies (Polytechnic Bulletin]. 2013; (3): 74–81. (in Russian)

45. Zhu L., Wu M., Li P., Zhou Y., Zhong J., Zhang Z., et al. High-pressure supercritical co2 extracts of ganoderma lucidum fruiting body and their anti-hepatoma effect associated with the Ras/Raf/MEK/ERK signaling pathway. Front Pharmacol. 2020; 11: 602702. DOI: https://doi.org/10.3389/fphar.2020.602702.Q1

46. Capuzzo A., Maffei M.E., Occhipinti A. Supercritical fluid extraction of plant flavors and fragrances. Molecules. 2013; 18: 7194–238. DOI: https://doi.org/10.3390/molecules18067194

47. Bossia S., Milanesib C., Maffeia M.E. Comparative analysis of supercritical CO2 extracts and essential oils from an Ocimum basilicum chemotype particularly rich in T-cadinol. J Essent Oil Res. 2013; 25 (4): 272–7. DOI: https://doi.org/10.1080/10412905.2013.775083

48. Grosso C., Oliveira A.C., Mainar A.M., Urieta J.S., Barroso J.G., Palavra A.M. Antioxidant activities of the supercritical and conventional Satureja montana extracts. J Food Sci. 2009; 74 (9): 713–7. DOI: https://doi.org/10.1111/j.1750-3841.2009.01376.x

49. Mushtaq M., Sultana B., Anwar F., Adnan A., Rizvi S.S.H. Enzyme-assisted supercritical fluid extraction of phenolic antioxidants from pomegranate peel. J Supercrit Fluids. 2015; 104: 122–31. DOI: https://doi.org/10.1016/j.supflu.2015.05.020

50. Lenucci M.S., De Caroli M., Marrese P.P., Iurlaro A., Rescio L., Böhm V., et al. Enzyme-aided extraction of lycopene from high-pigment tomato cultivars by supercritical carbon dioxide. Food Chem. 2015; 170: 193–202. DOI: https://doi.org/10.1016/j.foodchem.2014.08.081

51. Zorin S.N., Sidorova Yu. S., Petrov N.A., Perova I.B., Malinkin A.D., Bokov D.O., et al. A new functional food ingredient enriched by Phytoecdisteroids and Polyphenols from quinoa grains (Chenopodium quinoa Willd.). Res J Pharm Technol. 2021; 14 (8): 4321–8. DOI: https://doi.org/10.52711/0974-360X.2021.00750

52. Fattahi M., Rahimi R. Optimization of extraction parameters of phenolic antioxidants from leaves of Capparis spinosa using response surface methodology. Food Anal Methods. 2016; 9 (8): 2321–34. DOI: https://doi.org/10.1007/s12161-016-0414-9

53. Prakash Maran J., Manikandan S., Thirugnanasambandham K., Vigna Nivetha C., Dinesh R. Box-Behnken design based statistical modeling for ultrasound-assisted extraction of corn silk polysaccharide. Carbohydr Polym. 2013; 92 (1): 604–11. DOI: https://doi.org/10.1016/j.carbpol.2012.09.020

54. Shirzad H., Niknam V., Taheri M., Ebrahimzadeh H. Ultrasound-assisted extraction process of phenolic antioxidants from Olive leaves: a nutraceutical study using RSM and LC-ESI-DAD-MS. J Food Sci Technol. 2017; 54 (8): 2361–71. DOI: https://doi.org/10.1007/s13197-017-2676-7

55. Kadiri O., Gbadamosi S.O., Akanbi C.T. Extraction kinetics, modelling and optimization of phenolic antioxidants from sweet potato peel vis-a-vis RSM, ANN-GA and application in functional noodles. J Food Meas Char. 2019; 13 (11): 3267–84. DOI: https://doi.org/10.1007/s11694-019-00249-7

56. Sinha K., Chowdhury S., Saha P. Das, Datta S. Modeling of microwave-assisted extraction of natural dye from seeds of Bixa orellana (Annatto) using response surface methodology (RSM) and artificial neural network (ANN). Ind Crops Prod. 2013; 41 (1): 165–71. DOI: https://doi.org/10.1016/J.INDCROP.2012.04.004

57. Tan J., Li Q., Xue H., Tang J. Ultrasound-assisted enzymatic extraction of anthocyanins from grape skins: optimization, identification, and antitumor activity. J Food Sci. 2020; 85 (11): 3731–44. DOI: https://doi.org/10.1111/1750-3841.15497

58. Pal C.B.T., Jadeja G.C. Microwave-assisted extraction for recovery of polyphenolic antioxidants from ripe mango (Mangifera indica L.) peel using lactic acid/sodium acetate deep eutectic mixtures. Food Sci Technol Int. 2020; 26 (1): 78–92. DOI: https://doi.org/10.1177/1082013219870010

All articles in our journal are distributed under the CC BY-NC-ND 4.0 (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International)

© GEOTAR-Media Publishing Group. The use of textual and illustrative content from this publication for the training of any artificial intelligence systems - including machine learning models and neural networks - is strictly prohibited without the prior written consent of the copyright holder.

SCImago Journal & Country Rank
Scopus CiteScore
CHIEF EDITOR
CHIEF EDITOR
Viktor A. Tutelyan
Full Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Scientific Director of the Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia)

Journals of «GEOTAR-Media»