Role of calcium in health and reducing the risk of non-communicable diseases
AbstractCalcium as an essential mineral is involved in many processes in the body, being the main one in the mineral matrix of bones and teeth. It is necessary for conducting nerve impulses, blood coagulation, muscle contraction, regulation of the transport of various ions through the cell membrane, glycogenolysis and gluconeogenesis, and the activity of many enzymes. In Russia, insufficient calcium intake is noted.
The purpose of the work was to assess the role of calcium of various origins in meeting the needs and health of the population.
Material and methods. Literature search was carried out using the PubMed, Google Scholar, ResearchGate, RSCI, CyberLeninka systems, mainly for the last 10 years, with the exception of research of fundamental importance, using the keywords “calcium”, “milk ”, “bioavailability ”.
Results. Dairy consumption is associated with an overall reduction in the risk of noncommunicable diseases, including cardiovascular disease, type 2 diabetes mellitus, and some types of cancer. Calcium in natural milk and dairy products, as well as calcium of milk origin, has a higher bioavailability and absorption than from other sources of synthetic or natural mineral origin. The recommendation to reduce dairy consumption may be counterproductive to health and therefore may increase health care costs.
Conclusion. Milk and dairy products are the optimal source of calcium. The high bioavailability of calcium of milk origin justifies the expediency of its preferred use in dietary nutrition, both as part of therapeutic diets in hospitals and nutrition in social service institutions, and in outpatient practice. Additional studies, including randomized controlled trials, may be needed to explore in more detail the optimal consumption of milk and dairy products, as well as the use of calcium-containing pharmaceutical products and dietary supplements.
Keywords:calcium, milk; bioavailability; healthy nutrition; non-communicable diseases
Finding. Research work was carried out at the expense of the state budget for the implementation of the state assignment for research.
Conflict of interest. The authors declare no conflict of interest.
For citation: Baturin A.K., Sharafetdinov Kh.Kh., Kodentsova V.M. Role of calcium in health and reducing the risk of non-communicable diseases. Voprosy pitaniia [Problems of Nutrition]. 2022; 91 (1): 65-75. DOI: https://doi.org/10.33029/0042-8833-2022-91-1-65-75 (in Russian)
References
1. Nutritiology and clinical dietology. National guidance. Edited by V.A. Tutelyan, D.B. Nykityuk. Mossow: GEOTAR-Media; 2020: 1008 p. (in Russian)
2. Tutelyan V.A., Gerasimenko N.F., Nikityuk D.B., Pogozheva A.V. Optimal nutrition is the foundation of a healthy lifestyle. In: Youth health: new challenges and prospects: in 5 vols. Voronezh: Nauchnaya kniga. 2019; 3: Technologies to reduce health risks. Prevention and medical examination. Healthy food. 2019: 228–49. ISBN 978-5-6043289-2-7 (in Russian)
3. State policy of Russian Federation in the area of healthy nutrition. Report. Moscow: Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing; 2015: 89 p. (in Russian)
4. On the state of sanitary and epidemiological well-being of the population in Russian Federation in 2017: State report. Moscow: Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing; 2018: 268 p. (in Russian)
5. Baturin A.K., Martinchik A.N., Kambarov A.O. The structure of nutrition of the population of Russia at the turn of the XX and XXI centuries. Voprosy Pitaniia [Problems of Nutrition]. 2020; 89 (4): 60–70. DOI: https://doi.org/10.24411/0042-8833-2020-10042 (in Russian)
6. Drapkina O.M., Karamnova N.S., Kontsevaya A.V., Gorny B.E., Dadaeva V.A., Drozdova L.Yu., et al. Alimentary-dependent risk factors for chronic noncommunicable diseases and dietary habits: nutritional correction as part of preventive counseling. Guidelines. Kardiovaskulyarnaya terapiya i profilaktika [Cardiovascular Therapy and Prevention]. 2021; 20 (5): 2952. DOI: https://doi.org/10.15829/1728-8800-2021-2952 (in Russian)
7. Clinton S.K., Giovannucci E.L., Hursting S.D. The World Cancer Research Fund/American Institute for Cancer Research Third Expert Report on Diet, Nutrition, Physical Activity, and Cancer: Impact and Future Directions. J Nutr. 2020; 150 (4): 663–7. DOI: https://doi.org/10.1093/jn/nxz268
8. Lutsenko A.S., Rozhinskaya L.Ya., Toroptsova N.V., Belaya Zh.E. The role and place of calcium and vitamin D for the prevention and treatment of osteoporosis. Osteoporoz i osteopatii [Osteoporosis and Osteopathy]. 2017; 20 (2): 69–75. DOI: https://doi.org/10.14341/osteo9523 (in Russian)
9. Beto J.A. The role of calcium in human aging. Clin Nutr Res. 2015; 4: 1–8. DOI: http://dx.doi.org/10.7762/cnr.2015.4.1.1
10. Hartzell C.A., Jankowska K.I., Burkhardt J.K., Lewis R.S. Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse. Elife. 2016; 5: e14850. DOI: https://doi.org/10.7554/eLife.14850
11. Ermak G., Davies K.J. Calcium and oxidative stress: from cell signaling to cell death. Mol Immunol. 2002; 38 (10): 713–21. DOI: https://doi.org/10.1016/s0161-5890(01)00108-0
12. Sandow S.L., Senadheera S., Grayson T.H., Welsh D.G., Murphy T.V. Calcium and endothelium-mediated vasodilator signaling. Adv Exp Med Biol. 2012; 740: 811–31. DOI: https://doi.org/10.1007/978-94-007-2888-2_36
13. Sosa M., Bregni C. Metabolism of the calcium and bioavailability of the salts of most frequent use. Boll Chim Farm. 2003; 142 (1): 28–33.
14. Dawson-Hughes В. The role of calcium in bone growth and preservation. World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2017): Osteoporosis Int. 2017; 28 (S1): 99–126. DOI: https://doi.org/10.1007/s00198-017-3943-1
15. Kodentsova V.M., Risnik D.V., Pavlovich S.V., Ladodo O.B. Optimization of the trace element composition of breast milk, by enriching a women’s diet. Akusherstvo i ginekologiya [Obstetrics and Gynecology]. 2021; 8: 60–8. DOI: https://dx.doi.org/10.18565/aig.2021.8.60-68 (in Russian)
16. Shilin D.E. Pregnancy, lactation and calcium: baseless fears and proven success (100th anniversary of the first publication). Meditsinskiy sovet [Medical Council]. 2013; (8): 32–7. (in Russian) DOI: https://doi.org/10.21518/2079-701X-2013-8-32-37
17. Meir T., Levi R., Lieben L., Libutti S., Carmeliet G., Bouillon R., Naveh-Many T. Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology. Am J Physiol Ren Physiol. 2009; 297: F1192–8. DOI: https://doi.org/10.1152/ajprenal.00360.2009
18. Martinchik A.N., Keshabyants E.E., Peskova E.V., Mikhailov N.A., Baturin A.K. Dairy products and obesity: pro and contra, Russian experience. Voprosy pitaniia [Problems of Nutrition]. 2018; 87 (4): 39–47. DOI: https://doi.org/10.24411/0042-8833-2018-10040. (in Russian)
19. Caroli A., Poli A., Ricotta D., Banfi G., Cocchi D. Invited review: Dairy intake and bone health: a viewpoint from the state of the art. J Dairy Sci. 2011; 94 (11): 5249–62. DOI: https://doi.org/10.3168/jds.2011-4578
20. Marangoni F., Pellegrino L., Verduci E., Ghiselli A., Bernabei R., Calvani R., et al. Cow's Milk Consumption and Health: A Health Professional's Guide. J Am Coll Nutr. 2019; 38 (3): 197–208. DOI: https://doi.org/10.1080/07315724.2018.1491016
21. Kodentsova V.M., Risnik D.V. Fortified dairy products as a promising carrier of deficient micronutrients in the diet of Russians. Molochnaya promyshlennost' [Dairy industry]. 2021; (8): 58–61. DOI: https://doi.org/10.31515/1019-8946-2021-08-10-13 (in Russian)
22. Kodentsova V.M., Risnik D.V., Ladodo O.B. Vitamin consumption: contributions of separate products and effects of different diets. Meditsinskiy opponent [Medical Opponent]. 2021; 1 (13): 48–5. (in Russian)
23. Khan I.T., Nadeem M., Imran M., Ullah R., Ajmal M., Jaspal M.H. Antioxidant properties of milk and dairy products: a comprehensive review of the current knowledge. Lipids Health Dis. 2019; 18: 41. DOI: https://doi.org/10.1186/s12944-019-0969-8
24. Martinchik A.N., Keshabyants E.E., Kambarov A.O., Peskova E.V., Bryantseva S.A., Bazarova L.B., Semenova Ya.A. Dietary intake of calcium in pre-school and school children in Russia: main food sources and eating occasions. Voprosy pitaniia [Problems of Nutrition]. 2018; 87 (2): 24–33. (in Russian) DOI: https://doi.org/10.24411/0042-8833-2018-10015
25. Thorning T.K., Raben A., Tholstrup T., Soedamah-Muthu S.S., Givens I., Astrup A. Milk and dairy products: good or bad for human health? An assessment of the totality of scientific evidence. Food Nutr Res. 2016; 60: 32527. DOI: https://doi.org/10.3402/fnr.v60.32527
26. Rideout T.C., Marinangeli C.P., Martin H., Browne R.W., Rempel C.B. Consumption of low-fat dairy foods for 6 months improves insulin resistance without adversely affecting lipids or bodyweight in healthy adults: a randomized free-living cross-over study. Nutr J. 2013; 12: 56. DOI: https://doi.org/10.1186/1475-2891-12-56
27. Soedamah-Muthu S.S., Ding E.L., Al-Delaimy W.K., Hu F.B., Engberink M.F., Willett W.C., Geleijnse J.M. Milk and dairy consumption and incidence of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Am J Clin Nutr. 2011; 93 (1): 158–71. DOI: https://doi.org/10.3945/ajcn.2010.29866
28. Hu D., Huang J., Wang Y., Zhang D., Qu Y. Dairy foods and risk of stroke: a meta-analysis of prospective cohort studies. Nutr Metab Cardiovasc Dis. 2014; 24 (5): 460–9. DOI: https://doi.org/10.1016/j.numecd.2013.12.006
29. Sahni S., Mangano K.M., Kiel D.P., Tucker K.L., Hannan M.T. Dairy intake is protective against bone loss in older vitamin D supplement users: the Framingham Study. J Nutr. 2017; 147 (4): 645–52. DOI: https://doi.org/10.3945/jn.116.240390
30. Ralston R.A., Truby H., Palermo C.E., Walker K.Z. Colorectal cancer and nonfermented milk, solid cheese, and fermented milk consumption: a systematic review and meta-analysis of prospective studies. Crit Rev Food Sci Nutr. 2014; 54 (9): 1167–79. DOI: https://doi.org/10.1080/10408398.2011.629353
31. Diez-Fernández A., Álvarez-Bueno C., Martínez-Vizcaíno V., Sotos-Prieto M., Recio-Rodríguez J.I., Cavero-Redondo I. Total dairy, cheese and milk intake and arterial stiffness: a systematic review and meta-analysis of cross-sectional studies. Nutrients. 2019; 11 (4): 741. DOI: https://doi.org/10.3390/nu11040741
32. Cavero-Redondo I., Alvarez-Bueno C., Sotos-Prieto M., Gil A., Martinez-Vizcaino V., Ruiz J.R. Milk and dairy product consumption and risk of mortality: an overview of systematic reviews and meta-analyses. Adv Nutr. 2019; 10 (Suppl 2): S97–104. DOI: https://doi.org/10.1093/advances/nmy128
33. Fontecha J., Calvo M.V., Juarez M., Gil A., Martínez-Vizcaino V. Milk and dairy product consumption and cardiovascular diseases: An overview of systematic reviews and meta-analyses. Adv Nutr. 2019; 10 (Suppl 2): S164–89. DOI: https://doi.org/10.1093/advances/nmy099
34. Popova A.Yu., Tutelyan V.A., Nikityuk D.B. On the new (2021) Norms of physiological requirements in energy and nutrients of various groups of the population of the Russian Federation. Voprosy pitaniia [Problems of Nutrition]. 2021; 90 (4): 6–19. DOI: https://doi.org/10.33029/0042-8833-2021-90-4-6-19 (in Russian)
35. Melse-Boonstra A. Bioavailability of micronutrients from nutrient-dense whole foods: zooming in on dairy, vegetables, and fruits. Front Nutr. 2020 24; 7: 101. DOI: https://doi.org/10.3389/fnut.2020.00101
36. Mangano K.M., Walsh S.J., Insogna K.L., Kenny A.M., Kerstetter J.E. Calcium intake in the United States from dietary and supplemental sources across adult age groups: new estimates from the National Health and Nutrition Examination Survey 2003–2006. J Am Diet Assoc. 2011; 111 (5): 687–95. DOI: https://doi.org/10.1016/j.jada.2011.02.014
37. Balk E.M., Adam G.P., Langberg V.N., Earley A., Clark P., Ebeling P.R., et al.; International Osteoporosis Foundation Calcium Steering Committee. Global dietary calcium intake among adults: a systematic review. Osteoporos Int. 2017; 28 (12): 3315–24. DOI: https://doi.org/10.1007/s00198-017-4230-x
38. Baturin A.K. Nutritional status and ways to optimize it. Federal and regional aspects. All-Russian scientific-practical conference “Healthy food – healthy nation”. Moscow; 2009.
39. Shilin D.E. Calcium deficiency and other risk factors for osteoporotic fractures according to FRAX criteria (WHO, 2008) in the population of Russia and Kazakhstan: preliminary results of the international pilot project. Terapevticheskiy vestnik [Therapeutic Bulletin]. 2010; (2): 40–1. (in Russian)
40. Nikitinskaya O.A., Toroptsova N.V. Social program “Osteoscreening Russia” in action. Farmateka [Pharmateca]. 2012; (6): 90–3. (in Russian)
41. Suplotova L.A., Avdeeva V.A., Sharukho G.V. Assessment of the level of consumption of calcium and vitamin D with food in the adult population of Tyumen Region. Voprosy pitaniia [Problems of Nutrition]. 2019; 88 (5): 45–52. DOI: https://doi.org/10.24411/0042-8833-2019-10053 (in Russian)
42. Belaya Zh.E., Belova K.Yu., Biryukova E.V., Dedov I.I., Dzeranova L.K., Drapkina O.M., et al. Federal clinical guidelines for the diagnosis, treatment and prevention of osteoporosis. Osteoporoz i osteopatii [Osteoporosis and Osteopathy]. 2021; 24 (2): 4–47. DOI: https://doi.org/doi.org/10.14341/osteo12930 (in Russian)
43. Tang B.M., Eslick G.D., Nowson C., Smith C., Bensoussan A. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet. 2007; 370 (9588): 657–66. DOI: https://doi.org/10.1016/S0140-6736(07)61342-7
44. The chemical composition of food products used in the Russian Federation: http://web.ion.ru/food/FD_tree_grid.aspx (in Russian)
45. Guéguen L., Pointillart A. The bioavailability of dietary calcium. J Am Coll Nutr. 2000; 19 (2 Suppl): 119S–36S. DOI: https://doi.org/10.1080/07315724.2000.10718083
46. Kruger М.С., Gallaher B.W., Schollum L. Bioavailability of calcium is equivalent from milk fortified with either calcium carbonate or milk calcium in growing male rats. Nutr Res. 2003; 23 (9): 1229–37. DOI: https://doi.org/10.1016/S0271-5317(03)00100-3
47. Trailokya A., Srivastava A., Bhole M., Zalte N. Calcium and Calcium Salts. J Assoc Physicians India. 2017; 65 (2): 100–3.
48. Wiria M.S.S., Tran H.M., Nguyen P.H., Valencia O., Dutta S., Pouteau E. Relative bioavailability and pharmacokinetic comparison of calcium glucoheptonate with calcium carbonate. Pharmacol Res Perspect. 2020; 8 (2): e00589. DOI: https://doi.org/10.1002/prp2.589
49. Xu Y., Ye J., Zhou D., Su L. Research progress on applications of calcium derived from marine organisms. Sci Rep. 2020; 10 (1): 18425. DOI: https://doi.org/10.1038/s41598-020-75575-8
50. Gureev S.A., Mingazova E.N. On the question of the application of calcium preparations for the purpose of optimizing the diets of the population, including and for different diseases. Voprosy pitaniia [Problems of Nutrition]. 2021; 90 (2): 6–14. DOI: https://doi.org/10.33029/0042-8833-2021-90-2-6-14 (in Russian)
51. Osintsev A.M., Braginsky V.I., Rynk V.V., Chebotarev A.L. Specifics of milk and plant-based milk-like products coagulation. Food Processing: Techniques and Technology. 2018; 48 (3): 81–9. (in Russian). DOI: https://doi.org/10.21603/2074-9414-2018-3-81-89
52. Sheikh M.S., Santa Ana C.A., Nicar M.J., Schiller L.R., Fordtran J.S. Gastrointestinal absorption of calcium from milk and calcium salts. N Engl J Med. 1987; 317 (9): 532–6. DOI: https://doi.org/10.1056/NEJM198708273170903
53. Heaney R.P. Meta-analysis of calcium bioavailability. Am J Ther. 2001; 8 (1): 73–4. DOI: https://doi.org/10.1097/00045391-200101000-00011
54. Ilesanmi-Oyelere B.L., Kruger M.C. The role of milk components, pro-, pre-, and synbiotic foods in calcium absorption and bone health maintenance. Front Nutr. 2020; 7: 578702. DOI: https://doi.org/10.3389/fnut.2020.578702
55. Farrerons J., Olazabal A., Díaz López C., López Ciudad A, Rams A. An analysis of calcium pidolate absorption and a comparison with that of a salt in common use, gluconate-lactate-carbonate, in postmenopausal osteoporosis. An Med Interna. 1989; 6 (7): 361–5.
56. Booth A., Camacho P. A closer look at calcium absorption and the benefits and risks of dietary versus supplemental calcium. Postgrad Med. 2013; 125 (6): 73–81. DOI: https://doi.org/10.3810/pgm.2013.11.2714
57. Bonjour J.P., Chevalley T., Ammann P., Slosman D., Rizzoli R. Gain in bone mineral mass in prepubertal girls 3.5 years after discontinuation of calcium supplementation: a follow-up study. Lancet. 2001; 358 (9289): 1208–12. DOI: https://doi.org/10.1016/S0140-6736(01)06342-5
58. Eysteinsdottir T., Halldorsson T.I., Thorsdottir I., Sigurdsson G., Sigurðsson S., Harris T., Steingrimsdottir L. Milk consumption throughout life and bone mineral content and density in elderly men and women. Osteoporos Int. 2014; 25 (2): 663–72. DOI: https://doi.org/10.1007/s00198-013-2476-5
59. Shin C.S., Kim K.M. The risks and benefits of calcium supplementation. Endocrinol Metab (Seoul). 2015; 30 (1): 27–34. DOI: https://doi.org/10.3803/EnM.2015.30.1.27
60. Lee W.T., Leung S.S., Leung D.M., Wang S.H., Xu Y.C., Zeng W.P., et al. Bone mineral acquisition in low calcium intake children following the withdrawal of calcium supplement. Acta Paediatr. 1997; 86 (6): 570–6. DOI: https://doi.org/10.1111/j.1651-2227.1997.tb08936.x
61. Slemenda C.W., Peacock M., Hui S., Zhou, L., Johnston C.C. Reduced rates of skeletal remodeling are associated with increased bone mineral density during the development of peak skeletal mass. J Bone Miner Res. 1997; 12 (4): 676–82. DOI: https://doi.org/10.1359/jbmr.1997.12.4.676
62. Bonjour J.P., Carrie A.L., Ferrari S., Clavien H., Slosman D., Theintz G., et al. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial. J Clin Invest. 1997; 99 (6): 1287–94. DOI: https://doi.org/10.1172/JCI119287
63. Smart E.J., Gilchrist N.L., Maguire Р., Maguire P., March R., Hooke E.A., et al. Teenage girls dietary intake, attitude toward dairy products, and bone mineral density one year after the cessation of a Dairy Product Food Supplement Study. In: Burckhardt P., Dawson-Hughes B., Heaney R.P. (eds) Nutritional aspects of osteoporosis. Proceedings in the Serono Symposia USA Series. New York: Springer: 1998. DOI: https://doi.org/10.1007/978-1-4612-2228-6_4
64. Pointillart A., Coxam V., Sève B., Colin C., Lacroix C.H., Guéguen L. Availability of calcium from skim milk, calcium sulfate and calcium carbonate for bone mineralization in pigs. Reprod Nutr Dev. 2000; 40 (1): 49–61. DOI: https://doi.org/10.1051/rnd:2000119
65. Grinder-Pedersen L., Bukhave K., Jensen M., Højgaard L., Hansen M. Calcium from milk or calcium-fortified foods does not inhibit nonheme-iron absorption from a whole diet consumed over a 4-d period. Am J Clin Nutr. 2004; 80 (2): 404–9. DOI: https://doi.org/10.1093/ajcn/80.2.404l
66. Kristensen M., Jensen M., Kudsk J., Henriksen M., Mølgaard C. Short-term effects on bone turnover of replacing milk with cola beverages: a 10-day interventional study in young men. Osteoporos Int. 2005; 16: 1803–8. DOI: https://doi.org/10.1007/s00198-005-1935-z
67. Shkembi B., Huppertz T. Calcium absorption from food products: food matrix effects. Nutrients. 2022; 14 (1): 180. DOI: https://doi.org/10.3390/nu14010180
All articles in our journal are distributed under the CC BY-NC-ND 4.0 (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International)
© GEOTAR-Media Publishing Group. The use of textual and illustrative content from this publication for the training of any artificial intelligence systems - including machine learning models and neural networks - is strictly prohibited without the prior written consent of the copyright holder.